Reproductive Sciences and Sexual Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2024 Jul 23;14(1):16861. doi: 10.1038/s41598-024-67734-y.
Diminished ovarian reserve (DOR) is associated with reduced fertility and poor reproductive outcomes. The association between dietary patterns and DOR was not well studied. The purpose of this study was to evaluate the relationship between adhering to the healthy eating index (HEI-2015) and the risk of DOR. In this case-control study, 370 Iranian women (120 with DOR and 250 age- and BMI-matched controls) were examined. A reliable semi-quantitative food frequency questionnaire was used to collect diet-related data. We analyzed the HEI-2015 and their dietary intake data to determine major dietary patterns. The multivariable logistic regression was used in order to analyze the association between HEI-2015 and risk of DOR. We found no significant association between HEI-2015 score and risk of DOR in the unadjusted model (OR 0.78; 95%CI 0.59, 1.03). After controlling for physical activity and energy intake, we observed that women in the highest quartile of the HEI-2015 score had 31% decreased odds of DOR (OR 0.69; 95%CI 0.46, 0.93). This association remained significant even after adjusting for all potential confounders. Overall, increased adherence to HEI may lead to a significant reduction in the odds ratio of DOR. Clinical trials and prospective studies are needed to confirm this association.
卵巢储备功能降低（DOR）与生育能力下降和不良生殖结局有关。饮食模式与 DOR 之间的关系尚未得到充分研究。本研究旨在评估遵循健康饮食指数（HEI-2015）与 DOR 风险之间的关系。在这项病例对照研究中，检查了 370 名伊朗女性（120 名 DOR 患者和 250 名年龄和 BMI 匹配的对照者）。使用可靠的半定量食物频率问卷收集与饮食相关的数据。我们分析了 HEI-2015 及其饮食摄入数据，以确定主要的饮食模式。采用多变量逻辑回归分析 HEI-2015 与 DOR 风险之间的关系。我们发现，在未调整模型中，HEI-2015 评分与 DOR 风险之间没有显著关联（OR 0.78；95%CI 0.59,1.03）。在控制了体力活动和能量摄入后，我们发现 HEI-2015 评分最高四分位数的女性 DOR 风险降低了 31%（OR 0.69；95%CI 0.46,0.93）。即使在调整了所有潜在混杂因素后，这种关联仍然显著。总体而言，增加对 HEI 的依从性可能会导致 DOR 的比值比显著降低。需要进行临床试验和前瞻性研究来证实这种关联。
