Qin Bo, Moorman Patricia G, Kelemen Linda E, Alberg Anthony J, Barnholtz-Sloan Jill S, Bondy Melissa, Cote Michele L, Funkhouser Ellen, Peters Edward S, Schwartz Ann G, Terry Paul, Schildkraut Joellen M, Bandera Elisa V
Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
Department of Community and Family Medicine, Duke Cancer Institute, Durham, North Carolina.
Am J Epidemiol. 2017 Jun 15;185(12):1281-1289. doi: 10.1093/aje/kwx022.
This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders. We found that higher AHEI-2010 scores, but not HEI-2005 or HEI-2010 scores, were associated with lower risk of ovarian cancer (comparing the highest quartile (4th) vs. lowest (1st), odds ratio (OR) = 0.66, 95% confidence interval (CI): 0.45, 0.98; P for trend = 0.05). When stratified by menopausal status, no noteworthy associations were observed among premenopausal women. However, among postmenopausal women, greater adherence to HEI-2010 (quartile 4 vs. quartile 1, OR = 0.57, 95% CI: 0.36, 0.92; P for trend = 0.03) and AHEI-2010 (quartile 4 vs. quartile 1, OR = 0.49, 95% CI: 0.31, 0.78; P for trend = 0.01) were inversely associated with ovarian cancer. Our findings indicate that adherence to an overall healthy dietary pattern may reduce ovarian cancer risk in African-American women, and particularly among postmenopausal African-American women.
本研究评估了3种基于指数的饮食模式——2005年健康饮食指数（HEI）、2010年HEI和2010年替代健康饮食指数（AHEI）——与非裔美国女性卵巢癌风险的关系。该研究在从基于人群的非裔美国癌症流行病学研究中招募的415例卵巢癌病例和629名年龄及部位匹配的非裔美国对照中进行。采用多变量无条件逻辑回归模型来估计饮食质量指数四分位数与卵巢癌风险之间的比值比和95%置信区间，并对潜在混杂因素进行了校正。我们发现，较高的AHEI - 2010得分，但不是HEI - 2005或HEI - 2010得分，与较低的卵巢癌风险相关（比较最高四分位数（第4）与最低四分位数（第1），比值比（OR）= 0.66，95%置信区间（CI）：0.45，0.98；趋势P值 = 0.05）。按绝经状态分层时，在绝经前女性中未观察到显著关联。然而，在绝经后女性中，更高程度地遵循HEI - 2010（四分位数4与四分位数1相比，OR = 0.57，95% CI：0.36，0.92；趋势P值 = 0.03）和AHEI - 2010（四分位数4与四分位数1相比，OR = 0.49，95% CI：0.31，0.78；趋势P值 = 0.01）与卵巢癌呈负相关。我们的研究结果表明，遵循总体健康的饮食模式可能会降低非裔美国女性患卵巢癌的风险，尤其是在绝经后的非裔美国女性中。
