Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Reproduction and Development, Shanghai, China.
Reprod Biol Endocrinol. 2024 Nov 14;22(1):145. doi: 10.1186/s12958-024-01312-9.
Obesity and adverse lipid profile leads to female infertility. The cardiometabolic index (CMI) is a promising indicator for predicting obesity-related diseases. The correlation between CMI and female infertility merits further investigation.
The data for this study were acquired from the 2013-2020 National Health and Nutrition Examination Survey (NHANES), with 2333 women enrolled. The cardiometabolic index (CMI) of each participant was calculated as the ratio of triglycerides and high-density lipoprotein cholesterol multiplied by waist-to-height ratio. Weighted multivariate logistic regression models were used to assess the independent correlation between the log-transformed CMI and infertility. Subgroup analyses were carried out to assess the reliability of the findings. Interaction tests were employed to determine whether variables affected infertility by interacting with log CMI.
A total of 2333 participants aged 18-45 years were enrolled, 274 of whom were infertile. Log CMI of the infertility group was significantly higher than that of the non-infertility group (P < 0.001). After adjustment for potential confounders, women with higher CMI were at an increased risk of infertility (OR = 2.411, 95% CI: 1.416-4.112), and this correlation was still consistent in subgroups aged under 35 years (P < 0.001). Furthermore, restricted cubic spline analysis showed a positive non-linear relationship between log CMI and infertility.
Cardiometabolic index levels are positively correlated with increased risk of infertility in American females. Our study demonstrates the predictive capacity of CMI for female infertility.
肥胖和不良的血脂谱会导致女性不孕。心脏代谢指数（CMI）是预测肥胖相关疾病的有前途的指标。CMI 与女性不孕之间的相关性值得进一步研究。
本研究的数据来自 2013-2020 年全国健康与营养调查（NHANES），共纳入 2333 名女性。每位参与者的心脏代谢指数（CMI）计算为甘油三酯和高密度脂蛋白胆固醇的比值乘以腰高比。使用加权多变量逻辑回归模型评估对数 CMI 与不孕之间的独立相关性。进行亚组分析以评估研究结果的可靠性。进行交互检验以确定变量是否通过与对数 CMI 相互作用来影响不孕。
共纳入 2333 名 18-45 岁的参与者，其中 274 名患有不孕症。不孕组的对数 CMI 明显高于非不孕组（P<0.001）。在调整了潜在混杂因素后，CMI 较高的女性不孕的风险增加（OR=2.411，95%CI：1.416-4.112），这一相关性在年龄小于 35 岁的亚组中仍然一致（P<0.001）。此外，受限立方样条分析显示，对数 CMI 与不孕之间存在正相关的非线性关系。
心脏代谢指数水平与美国女性不孕的风险增加呈正相关。我们的研究表明 CMI 对女性不孕具有预测能力。
