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一种利用微芯片植入物监测个体活动和体温来评估群居大鼠膝关节疼痛的新方法。

A novel methodology utilizing microchip implants to monitor individual activity and body temperature for assessing knee pain in group-housed rats.

机构信息

Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

出版信息

Sci Rep. 2024 Jul 23;14(1):16909. doi: 10.1038/s41598-024-67024-7.

DOI:10.1038/s41598-024-67024-7
PMID:39043741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266718/
Abstract

The pain assessment in animals is challenging as they cannot verbally express the site and severity of pain. In this study, we tried a small implantable actimeter, "Nanotag", to monitor spontaneous locomotor activity and body temperature in animals suffering from a chemical-induced rat knee arthritis as compared to naïve and steroid-treated rats. Nanotag could detect the decrease in locomotor activity quickly after the arthritis induction and anti-inflammation analgesic treatment by intra-articular injection of steroid significantly improved locomotor activity. These changes were in the same line with those of a conventional knee pain evaluation method (incapacitance test). Nanotag can be utilized as the non-interventional, continuous, and completely objective monitoring the amount of pain in rat knee arthritis model. This traditional yet innovative method may be universally applicable to various pain models and species, making it a worthwhile device for research across diverse fields.

摘要

动物的疼痛评估具有挑战性，因为它们无法用言语表达疼痛的部位和严重程度。在这项研究中，我们尝试使用一种小型可植入的活动计“Nanotag”，来监测患有化学诱导的大鼠膝关节关节炎的动物的自发运动活动和体温，与未处理和接受类固醇治疗的大鼠进行比较。Nanotag 可以在关节炎诱导和关节内注射类固醇进行抗炎镇痛治疗后迅速检测到运动活动的减少，并且类固醇治疗明显改善了运动活动。这些变化与传统的膝关节疼痛评估方法（电容测试）一致。Nanotag 可用于非介入性、连续且完全客观地监测大鼠膝关节关节炎模型中的疼痛程度。这种传统而创新的方法可能普遍适用于各种疼痛模型和物种，因此对于跨多个领域的研究而言，这是一种非常有价值的设备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/8cea48bf5663/41598_2024_67024_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/e99da26953b8/41598_2024_67024_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/eba734c582f3/41598_2024_67024_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/003002e277af/41598_2024_67024_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/25301cceaf86/41598_2024_67024_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/92e8a2fb23ca/41598_2024_67024_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/8cea48bf5663/41598_2024_67024_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/e99da26953b8/41598_2024_67024_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/eba734c582f3/41598_2024_67024_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/003002e277af/41598_2024_67024_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/25301cceaf86/41598_2024_67024_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/92e8a2fb23ca/41598_2024_67024_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0a7/11266718/8cea48bf5663/41598_2024_67024_Fig6_HTML.jpg

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