Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt.
Department of Chemistry, Faculty of Science, Jazan University, Jazan, Saudi Arabia.
Sci Rep. 2024 Jul 23;14(1):16891. doi: 10.1038/s41598-024-65775-x.
Cancer, a lethal ailment, possesses a multitude of therapeutic alternatives to combat its presence, metal complexes have emerged as significant classes of medicinal compounds, exhibiting considerable biological efficacy, especially as anticancer agents. The utilization of cis-platin in the treatment of various cancer types, including breast cancer, has served as inspiration to devise novel nanostructured metal complexes for breast cancer therapy. Notably, homo- and hetero-octahedral bimetallic complexes of an innovative multifunctional ether ligand (comprising Mn(II), Ni(II), Cu(II), Zn(II), Hg(II), and Ag(I) ions) have been synthesized. To ascertain their structural characteristics, elemental and spectral analyses, encompassing IR, UV-Vis, H-NMR, mass and electron spin resonance (ESR) spectra, magnetic moments, molar conductance, thermal analysis, and electron microscopy, were employed. The molar conductance of these complexes in DMF demonstrated a non-electrolytic nature. Nanostructured forms of the complexes were identified through electron microscopic data. At ambient temperature, the ESR spectra of the solid complexes exhibited anisotropic and isotropic variants, indicative of covalent bonding. The ligand and several of its metal complexes were subjected to cytotoxicity testing against breast cancer protein 3S7S and liver cancer protein 4OO6, with the Ag(I) complex (7) evincing the most potent effect, followed by the Cu(II) with ligand (complex (2)), Cis-platin, the ligand itself, and the Cu(II)/Zn(II) complex (8). Molecular docking data unveiled the inhibitory order of several complexes.
癌症是一种致命的疾病，有许多治疗方法可以对抗它。金属配合物已成为一类重要的药物化合物，具有相当大的生物功效，特别是作为抗癌剂。顺铂在治疗包括乳腺癌在内的多种癌症类型中的应用为设计用于乳腺癌治疗的新型纳米结构金属配合物提供了灵感。值得注意的是，已经合成了一种创新多功能醚配体（包含 Mn(II)、Ni(II)、Cu(II)、Zn(II)、Hg(II) 和 Ag(I)离子）的同核和异核八面体双金属配合物。为了确定它们的结构特征，进行了元素和光谱分析，包括 IR、UV-Vis、H-NMR、质量和电子自旋共振 (ESR) 光谱、磁矩、摩尔电导率、热分析和电子显微镜。这些配合物在 DMF 中的摩尔电导率表明它们是非电解质。通过电子显微镜数据确定了配合物的纳米结构形式。在室温下，固体配合物的 ESR 光谱表现出各向异性和各向同性变体，表明存在共价键。对配体及其几种金属配合物进行了针对乳腺癌蛋白 3S7S 和肝癌蛋白 4OO6 的细胞毒性测试，Ag(I)配合物 (7) 表现出最强的效果，其次是配体的 Cu(II)（配合物 (2)）、顺铂、配体本身和 Cu(II)/Zn(II)配合物 (8)。分子对接数据揭示了几种配合物的抑制顺序。
