Department of Human Physiology, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Department of General Midwifery, School of Midwifery, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Sci Rep. 2024 Jul 23;14(1):16955. doi: 10.1038/s41598-024-68074-7.
Good-quality sleep is defined by its ability to minimize disturbances, provide adequate duration, and maintain a balanced progression through sleep stages. Sleep disturbance is a common complaint in people living with HIV/AIDS. Despite the influence of sleep disturbance on treatment adherence, quality of life, work productivity, risk of chronic illness. Studies have reported sleep disturbances among HIV/AIDS patients in sub-Saharan African countries (SSA), yielding varied results at the country level. Therefore, conducting a systematic review and meta-analysis is essential. This systematic review and meta-analysis aimed to evaluate the prevalence of poor sleep quality and identify associated factors among HIV/AIDS patients in sub-Saharan African countries. We systematically searched across various databases, including PubMed, African Journals Online, Scopus, Cochrane Library, HINARI, and Science Direct. Additionally, we conducted searches using Google and Google Scholar search engines. Microsoft Excel was used for data extraction, and the data were analysed using STAT version 17.0. We assessed heterogeneity using Cochran's Q test and I test and checked for small study effects using funnel plot symmetry and Egger's test. Pooled prevalence and associated factors were estimated using a random-effects model at a 95% confidence interval (CI) and significance level of p < 0.05. To identify factors associated with poor sleep quality among individuals living with HIV/AIDS, odds ratios (ORs) and their corresponding 95% CI were calculated. This analysis combined data from 15 separate studies involving a total sample size of 5176 participants. The pooled prevalence of poor sleep quality among HIV/AIDS patients in SSA countries was 49.32% (95% CI 41.32-56.8%). Factors significantly associated with poor sleep quality included depression (OR 2.78; 95% CI 1.21-6.40) and CD4 count < 200 cells/mm3 (AOR 3.15; 95% CI 2.41-4.15). In this study the prevalence of poor sleep quality among HIV/AIDS patients in SSA was higher and differs across the countries, ranging from 21.7 to 73.7%. The findings underscore the urgent necessity for programs aimed at improving sleep quality, particularly in addressing factors such as participant income and depression that are linked to poor sleep quality in HIV/AIDS patients.Systematic review registration: PROSPERO CRD42024517229.
优质睡眠的定义是能够最大限度地减少干扰、提供足够的持续时间，并保持睡眠阶段的平衡进展。睡眠障碍是艾滋病毒/艾滋病患者的常见抱怨。尽管睡眠障碍会影响治疗依从性、生活质量、工作效率和慢性疾病风险，但在撒哈拉以南非洲国家（SSA）的艾滋病毒/艾滋病患者中，研究报告的睡眠障碍结果存在差异。因此，进行系统评价和荟萃分析至关重要。本系统评价和荟萃分析旨在评估撒哈拉以南非洲国家艾滋病毒/艾滋病患者睡眠质量差的患病率，并确定相关因素。我们系统地在各种数据库中进行了搜索，包括 PubMed、African Journals Online、Scopus、Cochrane Library、HINARI 和 Science Direct。此外，我们还使用 Google 和 Google Scholar 搜索引擎进行了搜索。使用 Microsoft Excel 进行数据提取，并使用 STAT 版本 17.0 分析数据。我们使用 Cochran 的 Q 检验和 I 检验评估异质性，并使用漏斗图对称性和 Egger 检验检查小样本效应。使用随机效应模型在 95%置信区间（CI）和 p<0.05 的显著性水平下估计汇总患病率和相关因素。为了确定与艾滋病毒/艾滋病患者睡眠质量差相关的因素，计算了比值比（OR）及其相应的 95%CI。这项分析结合了来自 15 项独立研究的数据，涉及 5176 名参与者的总样本量。撒哈拉以南非洲国家艾滋病毒/艾滋病患者睡眠质量差的总体患病率为 49.32%（95%CI 41.32-56.8%）。与睡眠质量差显著相关的因素包括抑郁（OR 2.78；95%CI 1.21-6.40）和 CD4 计数<200 个细胞/mm3（AOR 3.15；95%CI 2.41-4.15）。在这项研究中，撒哈拉以南非洲国家艾滋病毒/艾滋病患者睡眠质量差的患病率较高，且在各国之间存在差异，范围从 21.7%到 73.7%不等。研究结果强调了迫切需要制定旨在改善睡眠质量的计划，特别是在解决与艾滋病毒/艾滋病患者睡眠质量差相关的因素方面，如参与者收入和抑郁。系统评价注册：PROSPERO CRD42024517229。
