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干细胞疗法在治疗HIV和艾滋病方面的前景:一篇叙述性综述

Promising Stem Cell therapy in the Management of HIV and AIDS: A Narrative Review.

作者信息

Kandula Usha Rani, Wake Addisu Dabi

机构信息

Department of Clinical Nursing, College of Health Sciences, Arsi University, Asella, Ethiopia.

出版信息

Biologics. 2022 Jul 8;16:89-105. doi: 10.2147/BTT.S368152. eCollection 2022.

Abstract

Stem cell therapies are becoming a major topic in biomedical research all over the planet. It may be a viable treatment choice for people suffering from a wide range of illnesses and injuries. It has recently emerged as an extremely intriguing and well-established science and research topic. Expectations have risen due to advancements in therapeutic approaches. Multiple laboratory testing of regulated stem cell culture and derivation is carried out before the formation of stem cells for the use of therapeutic process. Whereas HIV infection is contagious and can last a lifetime. Researchers are still working to develop a comprehensive and effective treatment for HIV and its associated condition, as well as AIDS. HIV propagation is primarily restricted to the immune system, notably T lymphocytes, as well as macrophages. Large numbers of research studies have contributed to a plethora of data about the enigmatic AIDS life cycle. This vast amount of data provides potential targets for AIDS therapies. Currently, stem cell transplantation, along with other procedures, provided novel insights into HIV pathogenesis and offered a glimpse of hope for the development of a viable HIV cure technique. One of its existing focus areas in HIV and AIDS research is to develop a novel therapeutic strategic plan capable of providing life-long complete recovery of HIV and AIDS without regular drug treatment and, inevitably, curative therapy for HIV and AIDS. The current paper tries to address the possibilities for improved stem cell treatments with "bone marrow, Hematopoietic, human umbilical cord mesenchymal, Genetical modifications with CRISPR/Cas9 in combination of stem cells, induced pluripotent stem cells applications" are discussed which are specifically applied in the HIV and AIDS therapeutic management advancement procedures.

摘要

干细胞疗法正成为全球生物医学研究的一个主要话题。对于患有多种疾病和损伤的人来说,它可能是一种可行的治疗选择。最近,它已成为一个极其引人入胜且成熟的科学研究课题。由于治疗方法的进步,人们的期望也随之提高。在形成用于治疗过程的干细胞之前,要对受监管的干细胞培养和衍生进行多次实验室测试。而艾滋病毒感染具有传染性且可能终生携带。研究人员仍在努力开发针对艾滋病毒及其相关病症以及艾滋病的全面有效治疗方法。艾滋病毒的传播主要局限于免疫系统,特别是T淋巴细胞以及巨噬细胞。大量的研究为有关神秘的艾滋病生命周期的大量数据做出了贡献。这些海量数据为艾滋病治疗提供了潜在靶点。目前,干细胞移植以及其他程序为艾滋病毒发病机制提供了新的见解,并为开发可行的艾滋病毒治愈技术带来了一线希望。艾滋病毒和艾滋病研究目前的重点领域之一是制定一种新的治疗战略计划,能够在不进行常规药物治疗的情况下实现艾滋病毒和艾滋病的终生完全康复,不可避免地,也就是实现艾滋病毒和艾滋病的治愈疗法。本文试图探讨通过“骨髓、造血、人脐带间充质、结合干细胞的CRISPR/Cas9基因改造、诱导多能干细胞应用”来改进干细胞治疗的可能性,这些方法特别应用于艾滋病毒和艾滋病治疗管理的推进过程中。

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HIV/AIDS: modified stem cells in the spotlight.艾滋病毒/艾滋病:改造后的干细胞成为焦点。
Cell Mol Life Sci. 2014 Jul;71(14):2641-9. doi: 10.1007/s00018-014-1572-9. Epub 2014 Feb 8.

本文引用的文献

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CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination.CRISPR-Cas9 介导的外显子干扰用于 HIV-1 的清除。
EBioMedicine. 2021 Nov;73:103678. doi: 10.1016/j.ebiom.2021.103678. Epub 2021 Nov 10.
9
Stem Cell Therapy and Its Significance in HIV Infection.干细胞疗法及其在HIV感染中的意义。
Cureus. 2021 Aug 27;13(8):e17507. doi: 10.7759/cureus.17507. eCollection 2021 Aug.

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