Ulshen M H, Herbst C A
Am J Clin Nutr. 1985 Nov;42(5):805-14. doi: 10.1093/ajcn/42.5.805.
To determine whether exposure to proximal intestinal contents per se is an adequate stimulus for ileal adaptation of the magnitude seen after jejunectomy, rats were prepared by transposing 30 cm of distal ileum to the duodenojejunal junction or by sham operation. One month after surgery, mucosal mass (wet weight, protein content, and DNA content) and digestive enzyme activities were measured in segments of small intestine and compared between the groups. Measurements of mucosal mass in transposed ileum more than doubled those in control jejunum (p less than 0.001). Mean enzyme activities/cm bowel length in transposed ileum approached or surpassed measurements in control jejunum. In contrast to the other enzymes studied, mean sucrase specific activities were similar in transposed ileum and control jejunum, values fivefold greater than that of control ileum (p less than 0.002). We conclude that exposure of ileum to proximal intestinal contents reproduces the adaptive response that follows jejunectomy, without requiring short bowel. Sucrase responds to this exposure in a unique fashion.
为了确定暴露于近端肠内容物本身是否是回肠适应的充分刺激因素，其程度与空肠切除术后所见相似，通过将30厘米的远端回肠移位至十二指肠空肠交界处或进行假手术来制备大鼠。手术后1个月，测量小肠各段的黏膜质量（湿重、蛋白质含量和DNA含量）和消化酶活性，并在组间进行比较。移位回肠的黏膜质量测量值比对照空肠增加了一倍多（p<0.001）。移位回肠每厘米肠长的平均酶活性接近或超过对照空肠的测量值。与所研究的其他酶相反，移位回肠和对照空肠中的平均蔗糖酶比活性相似，是对照回肠的五倍（p<0.002）。我们得出结论，回肠暴露于近端肠内容物可重现空肠切除术后的适应性反应，而无需短肠。蔗糖酶以独特的方式对这种暴露做出反应。
