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一家专科诊所中强迫观念与强迫行为及精神病风险症状的重叠情况。

Overlap of obsessive compulsive and psychosis risk symptoms in a specialized clinic.

作者信息

West Michelle L, Green James, Barber Madison E, Sharif Shadi, Lisowski Victoria, Friedman-Yakoobian Michelle

机构信息

Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

出版信息

Early Interv Psychiatry. 2025 Jan;19(1):e13596. doi: 10.1111/eip.13596. Epub 2024 Jul 23.

Abstract

AIM

Psychotic disorders and obsessive-compulsive disorder (OCD) commonly co-occur. Likewise, subthreshold psychosis symptoms (clinical high risk for psychosis; CHR) and obsessive compulsive symptoms (OCS) often overlap and may be difficult to differentiate. This study aimed to replicate research investigating the prevalence of OCD in a CHR clinic sample, validate and investigate factor structure of a self-report OCS measure in a CHR sample, explore how OCS may relate to CHR and co-occurring symptoms, and investigate whether real-world CHR treatment improves OCS and CHR symptoms.

METHOD

This study analysed archival clinical data from baseline and 6-month follow-up assessments collected by a specialist outpatient CHR clinic. Data included assessments of CHR symptoms, OCS, and clinician-rated diagnosis. Exploratory factor analysis examined the OCS measure.

RESULTS

Within this CHR clinic sample, 13.5% experienced co-morbid OCD. The self-report OCS measure had two factors: (1) checking and counting behaviours and (2) intrusive thoughts and images of harm/guilt. The checking and counting factor correlated with depression and social anxiety. The intrusive thoughts and images of harm/guilt factor significantly correlated with unusual thought content and social anxiety. Between baseline to 6-month follow-up, clients exhibited CHR symptom improvement regardless of OCD diagnosis. However, OCS did not change.

CONCLUSIONS

These findings support validity of a self-report OCS measure in a CHR clinic sample and that types of OCS experiences may exhibit different clinical patterns. Additionally, it appears that individuals with comorbid OCD responded similarly to CHR treatment compared to those without OCD.

摘要

目的

精神病性障碍与强迫症(OCD)常同时出现。同样,阈下精神病性症状(精神病临床高危;CHR)和强迫症状(OCS)也经常重叠,可能难以区分。本研究旨在重复关于CHR门诊样本中OCD患病率的研究,验证并研究CHR样本中一份自陈式OCS量表的因子结构,探讨OCS与CHR及共病症状的关系,以及研究现实中的CHR治疗是否能改善OCS和CHR症状。

方法

本研究分析了一家CHR专科门诊收集的基线和6个月随访评估的存档临床数据。数据包括CHR症状、OCS和临床医生评定诊断的评估。探索性因子分析检验了OCS量表。

结果

在这个CHR门诊样本中,13.5%的人患有共病OCD。自陈式OCS量表有两个因子:(1)检查和计数行为,以及(2)伤害/内疚的侵入性思维和意象。检查和计数因子与抑郁和社交焦虑相关。伤害/内疚的侵入性思维和意象因子与异常思维内容和社交焦虑显著相关。从基线到6个月随访期间,无论OCD诊断如何,患者的CHR症状都有所改善。然而,OCS没有变化。

结论

这些发现支持了自陈式OCS量表在CHR门诊样本中的有效性,以及OCS经历的类型可能表现出不同的临床模式。此外,与无OCD的个体相比,患有共病OCD的个体对CHR治疗的反应似乎相似。

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