Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, and the Neuropsychiatry Section of the Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA.
J Am Acad Child Adolesc Psychiatry. 2019 Feb;58(2):277-286.e4. doi: 10.1016/j.jaac.2018.06.038. Epub 2018 Nov 24.
Obsessive-compulsive symptoms (OCS) are common throughout development and often considered developmentally appropriate. We evaluated the prevalence and phenotypic heterogeneity of self-reported OCS in a large community youth sample not ascertained for seeking mental-health help. We aimed to identify patterns in OCS that are associated with serious psychopathology and may thus represent a "red flag" that merits psychiatric evaluation.
Data were analyzed from youth from the Philadelphia Neurodevelopmental Cohort (N = 7,054, aged 11-21 years, 54% female). Participants underwent structured psychiatric interviews, including screening for OCS (8 obsessions, 8 compulsions, and hoarding) and other major psychopathology domains. Factor analysis was conducted to identify clustering of OCS presentation. Regression models were used to investigate association of OCS with threshold lifetime diagnoses of obsessive-compulsive disorder (OCD), depressive episode, psychosis, and suicide ideation.
OCS were common in non-mental health-seeking individuals (38.2%), although only 3% met threshold OCD criteria. OCS were more common in female participants and postpuberty. Factor analyses resulted in 4 factors: F1 - Bad Thoughts; F2 - Repeating/Checking; F3 - Symmetry; F4 - Cleaning/Contamination; and Hoarding as a separate item. All OCS were associated with higher rates of OCD, depression, psychosis, and suicide ideation. However, endorsement of F1 symptoms, prevalent in more than 20% of the sample, showed the most substantial associations with major psychiatric conditions.
OCS are common in community youth. Although for most youths OCS symptoms may be benign, some patterns of OCS are associated with major psychiatric conditions. These findings may help to identify youth at risk for serious psychopathology.
强迫症症状(OCS)在整个发育过程中很常见,通常被认为是发育正常的。我们评估了一个未寻求心理健康帮助的大型社区青年样本中自我报告的 OCS 的患病率和表型异质性。我们旨在确定与严重精神病理学相关的 OCS 模式,这些模式可能代表需要进行精神评估的“红旗”。
分析了来自费城神经发育队列的青年数据(N=7054 名,年龄 11-21 岁,54%为女性)。参与者接受了结构化的精神病学访谈,包括强迫症筛查(8 种强迫观念、8 种强迫行为和囤积)和其他主要精神病理学领域。进行因子分析以确定 OCS 表现的聚类。回归模型用于调查 OCS 与阈上终生诊断的强迫症(OCD)、抑郁发作、精神病和自杀意念的关联。
在非寻求心理健康帮助的个体中,OCS 很常见(38.2%),尽管只有 3%符合 OCD 标准。OCS 在女性参与者和青春期后更常见。因子分析产生了 4 个因子:F1-不良想法;F2-重复/检查;F3-对称;F4-清洁/污染;以及作为单独项目的囤积。所有 OCS 与更高的 OCD、抑郁、精神病和自杀意念发生率相关。然而,在超过 20%的样本中普遍存在的 F1 症状的出现与主要精神疾病的关联最为显著。
OCS 在社区青年中很常见。尽管对于大多数青少年来说,OCS 症状可能是良性的,但某些 OCS 模式与严重的精神病理学相关。这些发现可能有助于识别有严重精神病理学风险的青少年。