Hostetler J A
Am J Med Genet. 1985 Nov;22(3):453-62. doi: 10.1002/ajmg.1320220303.
The social and cultural origins of the Hutterian Brethren, the most inbred population in North America, are described along with the characteristics that make the group useful for genetic studies. The Hutterites represent a closed population, with high levels of fertility and consanguinity. The group maintains a stable residence pattern and keeps extensive genealogic records. The uniform pattern of communal living, the existence of endogamous subgroups within the population, and an orderly design for colony fission facilitates comparisons rarely found in other accessible populations. This inbred population is useful for detecting new recessively inherited diseases, for advancing our knowledge of the effect of inbreeding, and for analyzing human chromosomal variation. Selected demographic and genetic studies are cited.
本文描述了北美近亲繁殖程度最高的群体哈特派兄弟会的社会文化起源，以及该群体对基因研究有用的特征。哈特派代表了一个封闭的群体，生育率和近亲结婚率都很高。该群体保持稳定的居住模式，并保留了详尽的族谱记录。群体生活的统一模式、群体内通婚亚群的存在以及殖民地裂变的有序设计，便于进行在其他可研究群体中很少见的比较。这个近亲繁殖群体有助于发现新的隐性遗传疾病，增进我们对近亲繁殖影响的了解，以及分析人类染色体变异。文中还引用了一些选定的人口统计学和遗传学研究。
