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基于生物信息学的蛋白质功能预测研究进展

[Advances in bioinformatics-based protein function prediction].

作者信息

He Xinyuan, Liu Yang, Zeng Xianghe, Gao Rongfeng, Tian Zhen, Fan Xiangyu

机构信息

School of Information Science and Engineering, University of Jinan, Jinan 250022, Shandong, China.

School of Biological Science and Technology, University of Jinan, Jinan 250022, Shandong, China.

出版信息

Sheng Wu Gong Cheng Xue Bao. 2024 Jul 25;40(7):2087-2099. doi: 10.13345/j.cjb.230675.

Abstract

With the increasing of computer power and rapid expansion of biological data, the application of bioinformatics tools has become the mainstream approach to address biological problems. The accurate identification of protein function by bioinformatics tools is crucial for both biomedical research and drug discovery, making it a hot topic of research. In this paper, we categorize bioinformatics-based protein function prediction methods into three categories: protein sequence-based methods, protein structure-based methods, and protein interaction networks-based methods. We further analyze these specific algorithms, highlighting the latest research advancements and providing valuable references for the application of bioinformatics-based protein function prediction in biomedical research and drug discovery.

摘要

随着计算机性能的不断提升以及生物数据的迅速膨胀,生物信息学工具的应用已成为解决生物学问题的主流方法。利用生物信息学工具准确识别蛋白质功能对于生物医学研究和药物研发均至关重要,这使其成为一个热门研究课题。在本文中,我们将基于生物信息学的蛋白质功能预测方法分为三类:基于蛋白质序列的方法、基于蛋白质结构的方法以及基于蛋白质相互作用网络的方法。我们进一步分析了这些具体算法,突出了最新的研究进展,并为基于生物信息学的蛋白质功能预测在生物医学研究和药物研发中的应用提供了有价值的参考。

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