Zhou Qiangqiang, Shi Zhaocheng, Xia Liyao, Mi Jing, Zhang Yuejiao, Xu Xiaobo, Pan Jie
Department of Operative Dentistry and Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
J Biomed Mater Res A. 2024 Dec;112(12):2301-2313. doi: 10.1002/jbm.a.37770. Epub 2024 Jul 23.
Over the past few decades, there have been advancements in the development of high-performance tissue adhesives as alternatives to traditional sutures and staples for rapid and effective wound closure post-surgery. While tissue adhesives offer advantages such as ease of use, short application time, and minimal tissue damage, they also face challenges related to biocompatibility, biodegradability, and adhesive strength. In this study, L-lysine diisocyanate (LDI) and trimethylolpropane (TMP) were utilized as the primary raw materials to produce a prepolymer terminated with NCO, resulting in the development of a new biocompatible polyurethane tissue adhesive (TMP-LDI). Additionally, SiO nanoparticles were incorporated into the prepolymer, significantly enhancing the adhesive strength of the TMP-LDI tissue adhesive through the "nanobridging effect," achieving a strength of 170.4 kPa. Furthermore, the SiO/TMP-LDI tissue adhesive exhibited satisfactory temperature change during curing and degradation performance. In vitro and in vivo studies demonstrated that SiO/TMP-LDI exhibited good biocompatibility, efficient hemostasis, antimicrobial properties, and the ability to promote wound healing. This research presents a novel approach for the development of tissue adhesives with superior adhesive performance.
在过去几十年里，高性能组织粘合剂的开发取得了进展，可作为传统缝线和吻合钉的替代品，用于手术后快速有效地闭合伤口。虽然组织粘合剂具有使用方便、应用时间短和对组织损伤最小等优点，但它们也面临着与生物相容性、生物降解性和粘合强度相关的挑战。在本研究中，L-赖氨酸二异氰酸酯（LDI）和三羟甲基丙烷（TMP）被用作主要原料来制备以NCO封端的预聚物，从而开发出一种新型生物相容性聚氨酯组织粘合剂（TMP-LDI）。此外，将SiO纳米颗粒掺入预聚物中，通过“纳米桥接效应”显著提高了TMP-LDI组织粘合剂的粘合强度，达到了170.4 kPa的强度。此外，SiO/TMP-LDI组织粘合剂在固化和降解过程中表现出令人满意的温度变化。体外和体内研究表明，SiO/TMP-LDI具有良好的生物相容性、高效止血、抗菌性能以及促进伤口愈合的能力。本研究提出了一种开发具有卓越粘合性能的组织粘合剂的新方法。
