College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center for Materials, Sichuan University, Chengdu 610065, China.
ACS Appl Mater Interfaces. 2024 Apr 3;16(13):15970-15980. doi: 10.1021/acsami.4c00924. Epub 2024 Mar 19.
Despite the rapid development of tissue adhesives, flaws including allergies, poor stability, and indiscriminate double-sided adhesive properties limit their application in the medical field. In this work, Janus polyurethane patches were spontaneously prepared by adjusting the difference in the functional group distribution between the top and bottom sides of the patch during emulsion drying. Consequently, poor adhesion was exhibited on the bottom surface, while the top surface can easily adhere to metals, polymers, glasses, and tissues. The difference in adhesive strength to pork skin between the two surfaces is more than 5 times. The quaternary ammonium salt and hydrophilic components on the surface of the polyurethane patch enable the rapid removal and absorption of water from the tissue surface to achieve wet adhesion. Animal experiments have demonstrated that this multifunctional Janus polyurethane patch can promote skin wound closure and healing of infected wounds. This facile and effective strategy to construct Janus polyurethane patch provides a promising method for the development of functional tissue-adhesives.
尽管组织粘合剂发展迅速，但包括过敏、稳定性差和不分双面胶性质在内的缺陷限制了它们在医学领域的应用。在这项工作中，通过在乳液干燥过程中调整贴片上下表面的官能团分布差异，自发制备了 Janus 型聚氨酯贴片。因此，贴片的下表面表现出较差的粘附性，而上表面可以很容易地粘附到金属、聚合物、玻璃和组织上。两面之间对猪皮的粘附强度差异超过 5 倍。聚氨酯贴片表面的季铵盐和亲水成分使水能够从组织表面迅速去除和吸收，从而实现湿粘附。动物实验表明，这种多功能 Janus 型聚氨酯贴片可以促进皮肤伤口闭合和感染伤口的愈合。这种构建 Janus 型聚氨酯贴片的简便有效策略为功能性组织粘合剂的发展提供了一种有前途的方法。
