Silva Sandra, Fernandes João, Campainha Sérgio, Sanches Agostinho, Marques Cristiana
Medical Oncology, Unidade Local de Saúde Gaia/Espinho, Vila Nova de Gaia, PRT.
Radiology, Unidade Local de Saúde Gaia/Espinho, Vila Nova de Gaia, PRT.
Cureus. 2024 Jun 23;16(6):e62939. doi: 10.7759/cureus.62939. eCollection 2024 Jun.
Sarcoidosis presents a diagnostic challenge due to its diverse clinical manifestations and potential to mimic malignancies. We report a clinical case involving a 46-year-old woman diagnosed with localized synchronous ovarian and endometrial carcinomas treated with surgery. Following adjuvant chemotherapy and radiotherapy, the patient developed suspicious pulmonary micronodules and lymphadenopathy observed in imaging studies, raising concerns about cancer recurrence. Histopathological analysis revealed chronic granulomatous inflammation without evidence of malignancy, leading to a diagnosis of a sarcoidosis-like reaction secondary to chemotherapy. Remarkably, these lesions resolved spontaneously without specific intervention. This case emphasizes the importance of a multidisciplinary approach in managing complex oncological presentations and underscores the significance of histopathological examination in distinguishing between malignancy and chemotherapy-induced sarcoidosis-like reactions.
结节病因其临床表现多样且有模仿恶性肿瘤的可能，给诊断带来了挑战。我们报告了一例临床病例，患者为一名46岁女性，被诊断为局限性同步性卵巢癌和子宫内膜癌，接受了手术治疗。在辅助化疗和放疗后，患者在影像学检查中出现可疑的肺部微小结节和淋巴结病，引发了对癌症复发的担忧。组织病理学分析显示为慢性肉芽肿性炎症，无恶性肿瘤证据，最终诊断为化疗继发的结节病样反应。值得注意的是，这些病变未经特殊干预即自行消退。该病例强调了多学科方法在处理复杂肿瘤病例中的重要性，并突出了组织病理学检查在区分恶性肿瘤和化疗引起的结节病样反应方面的重要意义。
