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病例报告:Wilms 瘤中的胸腔积液——总是恶性的吗?

Case Report: Pleural effusion in Wilms tumor - always malignant?

机构信息

Pediatrics, Jawaharlal Nehru Medical College, Wardha, Maharashtra, 442001, India.

Hemato-Oncology and Bone Marrow Transplant, Royal Manchester Children's Hospital, Manchester, M139WL, UK.

出版信息

F1000Res. 2023 Aug 30;12:1056. doi: 10.12688/f1000research.138794.1. eCollection 2023.

DOI:10.12688/f1000research.138794.1
PMID:39045042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11263906/
Abstract

Wilms tumor (WT) is the most common renal malignancy seen in pediatric patients. Although lungs are the most common site of metastasis in Wilms tumor, non-malignant pleural effusion has been infrequently reported. Here, we report a case of an eleven-year-old female who presented with an abdominal mass and progressive breathlessness. On further evaluation, she was found to have a right-sided Wilms tumor with ipsilateral massive pleural effusion. The effusion resolved almost completely after four weeks of chemotherapy. We conclude that patients suffering from Wilms tumor presenting with pleural effusion need not be synonymous with metastatic disease and can have a favorable prognosis.

摘要

威尔姆斯瘤(WT)是儿科患者中最常见的肾脏恶性肿瘤。虽然肺部是威尔姆斯瘤最常见的转移部位,但良性胸腔积液的报道很少见。在这里,我们报告了一例 11 岁女性,她因腹部肿块和进行性呼吸困难就诊。进一步评估发现,她患有右侧威尔姆斯瘤,并伴有同侧大量胸腔积液。化疗四周后,胸腔积液几乎完全消退。我们得出结论,患有威尔姆斯瘤并伴有胸腔积液的患者不一定等同于转移性疾病,并且可以有良好的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/09a254759fef/f1000research-12-152024-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/3bd62bfeb02a/f1000research-12-152024-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/cd845012ca1c/f1000research-12-152024-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/09a254759fef/f1000research-12-152024-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/3bd62bfeb02a/f1000research-12-152024-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/cd845012ca1c/f1000research-12-152024-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4727/11263906/09a254759fef/f1000research-12-152024-g0002.jpg

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Case Report: Pleural effusion in Wilms tumor - always malignant?病例报告:Wilms 瘤中的胸腔积液——总是恶性的吗?
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本文引用的文献

1
Malignant Pleural Effusion: Diagnosis and Management.恶性胸腔积液:诊断与管理。
Can Respir J. 2020 Sep 23;2020:2950751. doi: 10.1155/2020/2950751. eCollection 2020.
2
Wilms Tumor with Pleural Metastasis.伴有胸膜转移的肾母细胞瘤
Glob Pediatr Health. 2020 Aug 27;7:2333794X20952292. doi: 10.1177/2333794X20952292. eCollection 2020.
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Wilms tumour event-free and overall survival in Southern and Eastern Europe: Pooled analyses of clinical data from four childhood cancer registries (1999-2017).威尔姆斯瘤无事件生存和总体生存情况在南欧和东欧:四个儿童癌症登记处(1999-2017 年)的临床数据汇总分析。
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Wilms tumor.肾母细胞瘤
Pediatr Rev. 2013 Jul;34(7):328-30; discussion 330. doi: 10.1542/pir.34-7-328.
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Pleural effusion in Wilms tumor after tru-cut biopsy.经皮穿刺活检后肾母细胞瘤出现胸腔积液。
Pediatr Hematol Oncol. 2007 Oct-Nov;24(7):555-8. doi: 10.1080/08880010701534114.
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Malignant renal tumours incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project.欧洲儿童恶性肾肿瘤的发病率与生存率(1978 - 1997年):儿童癌症自动信息系统项目报告
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Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.胸腔积液中转移性上皮性肾母细胞瘤的细胞学鉴定:一例报告并文献复习
Diagn Cytopathol. 2006 Sep;34(9):621-5. doi: 10.1002/dc.20535.
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Significance of pleural effusion at diagnosis of Wilms tumor.肾母细胞瘤诊断时胸腔积液的意义。
Pediatr Blood Cancer. 2004 Feb;42(2):145-8. doi: 10.1002/pbc.10429.
9
Cytology of pleural, peritoneal and pericardial fluids in children. A 40-year summary.儿童胸腔、腹腔和心包积液的细胞学检查。40年总结。
Acta Cytol. 1997 Mar-Apr;41(2):467-73. doi: 10.1159/000332540.
10
Wilms' tumor: cure of malignant pleural effusion exclusively with chemotherapy.肾母细胞瘤:单纯化疗治愈恶性胸腔积液。
Med Pediatr Oncol. 1995 Apr;24(4):274-7. doi: 10.1002/mpo.2950240413.