Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Pesquisas em Estresse Oxidativo, Av. Augusto Correa, 01, 66075-110 Belém, PA, Brazil.
Programa de Pós-Graduação em Biodiversidade e Biotecnologia - Rede BIONORTE, Universidade Federal do Pará, Instituto de Ciências Biológicas, Av. Augusto Correa, 01, 66075-110 Belém, PA, Brazil.
An Acad Bras Cienc. 2024 Jul 19;96(3):e20230347. doi: 10.1590/0001-3765202420230347. eCollection 2024.
Oxidative stress is involved in the pathogenesis of malaria, causing anemia, respiratory complications, and cerebral malaria. To mitigate oxidative stress, we investigated the effect of nutritional supplementation whit lycopene (LYC) on the evolution of parasitemia and survival rate in mice infected with Plasmodium berghei ANKA (Pb), comparing to the effects promoted by N-acetylcysteine (NAC). Therefore, 175 mice were randomly distributed into 4 groups; Sham: untreated and uninfected animals; Pb: animals infected with Pb; LYC+Pb: animals treated with LYC and infected with Pb; NAC+Pb: animals treated with NAC and infected with Pb. The animals were followed for 12 days after infection, and survival and parasitemia rates were evaluated. There was a 40.1% increase in parasitemia in the animals of the Pb group on the 12th day, and a survival rate of 45%. LYC supplementation slowed the development of parasitemia to 19% and promoted a significative increase in the survival rate of 80% on the 12th day after infection, compared to the Pb group, effects superior to those promoted by NAC, providing strong evidence of the beneficial effect of LYC on in vivo malaria and stressing the importance of antioxidant supplementation in the treatment of this disease.
氧化应激参与疟疾的发病机制，导致贫血、呼吸并发症和脑型疟疾。为了减轻氧化应激，我们研究了营养补充剂番茄红素（LYC）对感染伯氏疟原虫 ANKA（Pb）的小鼠寄生虫血症和存活率演变的影响，并与 N-乙酰半胱氨酸（NAC）的影响进行了比较。因此，将 175 只小鼠随机分为 4 组：Sham：未处理且未感染的动物；Pb：感染 Pb 的动物；LYC+Pb：用 LYC 处理并感染 Pb 的动物；NAC+Pb：用 NAC 处理并感染 Pb 的动物。在感染后 12 天内对动物进行跟踪，评估存活率和寄生虫血症率。在第 12 天，Pb 组的寄生虫血症增加了 40.1%，存活率为 45%。LYC 补充剂将寄生虫血症的发展速度减缓至 19%，并在感染后第 12 天显著提高 80%的存活率，与 Pb 组相比，效果优于 NAC 组，这为 LYC 对体内疟疾的有益作用提供了有力证据，并强调了抗氧化剂补充在治疗这种疾病中的重要性。
