School of Life Science and Technology, the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, People's Republic of China.
Open Biol. 2024 Jul;14(7):240059. doi: 10.1098/rsob.240059. Epub 2024 Jul 24.
The brain can adapt to changes in the environment through alterations in the number and structure of synapses. During embryonic and early postnatal stages, the synapses in the brain undergo rapid expansion and interconnections to form circuits. However, many of these synaptic connections are redundant or incorrect. Neurite pruning is a conserved process that occurs during both vertebrate and invertebrate development. It requires precise spatiotemporal control of local degradation of cellular components, comprising cytoskeletons and membranes, refines neuronal circuits, and ensures the precise connectivity required for proper function. The 's class IV dendritic arborization (C4da) sensory neuron has a well-characterized architecture and undergoes dendrite-specific sculpting, making it a valuable model for unravelling the intricate regulatory mechanisms underlie dendritic pruning. In this review, I attempt to provide an overview of the present state of research on dendritic pruning in C4da sensory neurons, as well as potential functional mechanisms in neurodevelopmental disorders.
大脑可以通过突触数量和结构的改变来适应环境的变化。在胚胎期和出生后的早期阶段，大脑中的突触会迅速扩张并相互连接，形成回路。然而，其中许多突触连接是冗余或不正确的。神经突修剪是一个保守的过程，发生在脊椎动物和无脊椎动物的发育过程中。它需要精确的时空控制细胞成分的局部降解，包括细胞骨架和膜，精细地调整神经元回路，并确保适当功能所需的精确连接。's 类 IV 树突状分支（C4da）感觉神经元具有特征明显的结构，并经历树突特异性的塑造，使其成为揭示神经发育障碍中复杂调节机制的有价值模型。在这篇综述中，我试图提供 C4da 感觉神经元中树突修剪的研究现状概述，以及神经发育障碍中的潜在功能机制。
