钯催化吲哚与芳基甲酸酯的串联Heck环化/羰基化反应：对映选择性构建吲哚并[2,1-]异喹啉
Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-]isoquinolines.
作者信息
Chi Dongmei, Qi Hongbo, Wang Leming, Chen Shufeng
机构信息
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China.
出版信息
Chem Commun (Camb). 2024 Aug 9;60(65):8613-8616. doi: 10.1039/d4cc02577f.
PMID:39046243
Abstract
An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1-]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1-]isoquinoline products in good yields and enantioselectivities.
摘要
已开发出一种高效的钯催化吲哚与芳基甲酸酯的串联环化/羰基化反应，以构建酯官能化的吲哚并[2,1-]异喹啉骨架。此外，使用手性膦配体还实现了不对称变体，以良好的产率和对映选择性得到吲哚并[2,1-]异喹啉产物。
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