Ye Hao, Wu Linhui, Zhang Minrui, Jiang Guomin, Dai Hong, Wu Xin-Xing
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, P. R. China.
Chem Commun (Camb). 2022 Jun 14;58(48):6825-6828. doi: 10.1039/d2cc02152h.
We report herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, applying formates as a convenient carbonyl source. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines an intramolecular reductive cyclization after the palladium-catalyzed process.
我们在此报告一种钯催化的多米诺环化/羰基化反应，以制备酯官能化的氮杂吲哚啉，使用甲酸酯作为方便的羰基源。构建了所有四种氮杂吲哚啉异构体，显示出良好的官能团兼容性。在此基础上，对氨基吡啶上的起始连接基进行修饰，导致在钯催化过程后发生分子内还原环化生成呋咱氮杂吲哚啉。
