Luo Anna, Oliver Fergus, Kennedy Harriet
Department of Dermatology, Greenlane Clinical Centre, Te Whatu Ora, Auckland, New Zealand.
Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Australas J Dermatol. 2024 Dec;65(8):647-649. doi: 10.1111/ajd.14349. Epub 2024 Jul 24.
The term 'hyperkeratotic flexural erythema' (HFE) has been used synonymously with granular parakeratosis (GP), to describe a scaly, typically intertriginous rash associated with contact factors such as benzalkonium chloride. However, clinical HFE can occur without the classical GP histological pattern. We reviewed skin biopsies from 10 patients with clinically diagnosed HFE. A progression of histopathological features is suggested. The absence of histological GP should not exclude the clinical diagnosis of HFE when there is a high index of suspicion.
术语“角化过度性屈侧红斑”（HFE）一直与颗粒状角化不全（GP）同义使用，用于描述一种鳞屑性皮疹，通常为间擦疹，与诸如苯扎氯铵等接触因素有关。然而，临床上HFE可在无典型GP组织学模式的情况下发生。我们回顾了10例临床诊断为HFE患者的皮肤活检。提示存在组织病理学特征的进展。当怀疑指数较高时，组织学上不存在GP不应排除HFE的临床诊断。
