Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Napoli, Italy.
Neuropsychology Laboratory, Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Curr Neurol Neurosci Rep. 2024 Oct;24(10):461-477. doi: 10.1007/s11910-024-01365-8. Epub 2024 Jul 24.
In this review, we attempt to summarize the most updated studies that applied resting-state functional magnetic resonance imaging (rs-fMRI) in the field of Parkinsonisms and related dementia.
Over the past decades, increasing interest has emerged on investigating the presence and pathophysiology of cognitive symptoms in Parkinsonisms and their possible role as predictive biomarkers of neurodegenerative brain processes. In recent years, evidence has been provided, applying mainly three methodological approaches (i.e. seed-based, network-based and graph-analysis) on rs-fMRI data, with promising results. Neural correlates of cognitive impairment and dementia have been detected in patients with Parkinsonisms along the diseases course. Interestingly, early functional connectivity signatures were proposed to track and predict future progression of neurodegenerative processes. However, longitudinal studies are still sparce and further investigations are needed to overcome this knowledge gap.
在本篇综述中，我们试图总结应用静息态功能磁共振成像(rs-fMRI)于帕金森病及相关痴呆领域的最新研究。
过去几十年来，人们对帕金森病患者认知症状的存在及其病理生理学，以及它们作为神经退行性脑过程预测生物标志物的可能作用越来越感兴趣。近年来，已经应用 rs-fMRI 数据主要通过三种方法学途径（即种子法、网络法和图分析）提供了证据，结果很有前景。在帕金森病患者中，沿着疾病进程可以检测到认知障碍和痴呆的神经相关性。有趣的是，早期功能连接特征被提出用于跟踪和预测神经退行性过程的未来进展。然而，纵向研究仍然很少，需要进一步的研究来弥补这一知识空白。
