Chen Kaidong, Zhang Li, Wang Feng, Mao Haixia, Tang Qunfeng, Shi Guofeng, You Yiping, Yuan Qingfang, Chen Bixue, Fang Xiangming
Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299, Qingyang Road, Liangxi District, Wuxi, 214023, Jiangsu Province, China.
Department of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299, Qingyang Road, Liangxi District, Wuxi, 214023, Jiangsu Province, China.
Heliyon. 2023 May 2;9(5):e15871. doi: 10.1016/j.heliyon.2023.e15871. eCollection 2023 May.
Aimed to investigate whether there are abnormal changes in the functional connectivity (FC) between the amygdala with other brain areas, in Parkinson's disease (PD) patients with anxiety.
Participants were enrolled prospectively, and the Hamilton Anxiety Rating (HAMA) Scale was used to quantify anxiety disorder. Rest-state functional MRI (rs-fMRI) was applied to analyze the amygdala FC patterns among anxious PD patients, non-anxious PD patients, and healthy controls.
Thirty-three PD patients were recruited, 13 with anxiety, 20 without anxiety, and 19 non-anxious healthy controls. In anxious PD patients, FC between the amygdala with the hippocampus, putamen, intraparietal sulcus, and precuneus showed abnormal alterations compared with non-anxious PD patients and healthy controls. In particular, FC between the amygdala and hippocampus negatively correlated with the HAMA score (r = -0.459, p = 0.007).
Our results support the role of the fear circuit in emotional regulation in PD with anxiety. Also, the abnormal FC patterns of the amygdala could preliminarily explain the neural mechanisms of anxiety in PD.
旨在研究伴有焦虑的帕金森病（PD）患者杏仁核与其他脑区之间的功能连接（FC）是否存在异常变化。
前瞻性纳入参与者，使用汉密尔顿焦虑量表（HAMA）对焦虑症进行量化。应用静息态功能磁共振成像（rs-fMRI）分析焦虑型PD患者、非焦虑型PD患者和健康对照者的杏仁核FC模式。
招募了33例PD患者，其中13例伴有焦虑，20例不伴有焦虑，以及19例非焦虑健康对照者。与非焦虑型PD患者和健康对照者相比，焦虑型PD患者杏仁核与海马、壳核、顶内沟和楔前叶之间的FC显示出异常改变。特别是，杏仁核与海马之间的FC与HAMA评分呈负相关（r = -0.459，p = 0.007）。
我们的结果支持恐惧回路在伴有焦虑的PD患者情绪调节中的作用。此外，杏仁核的异常FC模式可以初步解释PD患者焦虑的神经机制。
