梅毒螺旋体感染中自身淋巴细胞毒性活性的研究。
Studies on autolymphocytotoxic activity occurring in Treponema pallidum infection.
作者信息
Podwińska J, Farbiszewska-Achramowicz A
出版信息
Arch Immunol Ther Exp (Warsz). 1985;33(3):405-11.
It was found that in sera of majority of syphilitic rabbits cold lymphocytotoxic activity occurs. This activity appears usually 3 to 10 weeks after infection and it is present for 9 to 10 weeks. Lymphocytotoxic activity was found in undiluted sera or diluted from 1/2 to 1/8. This activity was directed against B lymphocytes only. Lymphocytotoxicity was found only in sera with high level of VDRL antibodies. The role of this activity in syphilis is not known. The killing effect exerted on B lymphocytes producing syphilitic reagins directed not only against T. pallidum, suggests that lymphocytotoxic activity may take part in the regulation of humoral response at the beginning of syphilitic infection.
研究发现，大多数梅毒兔血清中存在冷淋巴细胞毒性活性。这种活性通常在感染后3至10周出现，并持续9至10周。在未稀释的血清或稀释至1/2至1/8的血清中发现淋巴细胞毒性活性。这种活性仅针对B淋巴细胞。仅在VDRL抗体水平高的血清中发现淋巴细胞毒性。这种活性在梅毒中的作用尚不清楚。对产生不仅针对梅毒螺旋体的梅毒反应素的B淋巴细胞产生的杀伤作用表明，淋巴细胞毒性活性可能在梅毒感染初期参与体液反应的调节。
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