显著的垂体铁沉积在依赖输血的镰状细胞病中很常见。
Significant pituitary siderosis is common in transfusion-dependent sickle cell disease.
机构信息
Division of Pediatric Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, CA.
Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, CA.
出版信息
Blood. 2024 Sep 26;144(13):1457-1459. doi: 10.1182/blood.2024025462.
Abstract
Chronically transfused patients with sickle cell disease typically do not exhibit iron-mediated extrahepatic toxicity. However, we demonstrate that the pituitary gland is vulnerable to iron deposition, and it occurs regardless of other extrahepatic involvement. Severe pituitary siderosis is associated with early organ dysfunction.
摘要
慢性输血的镰状细胞病患者通常不会表现出铁介导的肝外毒性。然而，我们证明垂体容易受到铁沉积的影响，而且这种情况发生与其他肝外受累无关。严重的垂体含铁血黄素沉着症与早期器官功能障碍有关。
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