输血依赖型镰状细胞病中胰腺铁的患病率及意义
Prevalence and Significance of Pancreatic Iron in Transfusion-Dependent Sickle Cell Disease.
作者信息
Vadivelan Akhila, Doyle Eamon, Carson Susan, Denton Christopher, Veluswamy Saranya, Hofstra Thomas, Coates Thomas, Wood John C
机构信息
Department of Pediatrics, Division of Pediatric Hematology/Oncology, UCLA Mattel Children's Hospital, Los Angeles, California, USA.
Department of Clinical Radiology, USC Keck School of Medicine, Children's Hospital of Los Angeles, Los Angeles, California, USA.
出版信息
Pediatr Blood Cancer. 2025 Aug;72(8):e31780. doi: 10.1002/pbc.31780. Epub 2025 May 12.
BACKGROUND
Chronically transfused patients with sickle cell disease (SCD) and beta thalassemia major (TM) develop iron overload.
OBJECTIVE
Determine the impact of iron overload on glucose regulation in SCD.
METHODS
Prospective study of 28 patients with SCD and 38 patients with TM who underwent liver and pancreas R* measurements and oral glucose tolerance tests.
RESULTS
Impaired fasting glucose (2 vs. 9, p = 0.27) and impaired glucose tolerance (1 vs. 11, p = 0.019) were less common in patients with SCD compared with patients with TM. No SCD patient had diabetes.
CONCLUSION
Iron-mediated glucose dysregulation is present but less common in SCD patients.
背景
患有镰状细胞病（SCD）和重型β地中海贫血（TM）的长期输血患者会出现铁过载。
目的
确定铁过载对SCD患者葡萄糖调节的影响。
方法
对28例SCD患者和38例TM患者进行前瞻性研究，这些患者接受了肝脏和胰腺R*测量以及口服葡萄糖耐量试验。
结果
与TM患者相比，SCD患者空腹血糖受损（2例对9例，p = 0.27）和葡萄糖耐量受损（1例对11例，p = 0.019）的情况较少见。没有SCD患者患有糖尿病。
结论
铁介导的葡萄糖调节异常存在，但在SCD患者中较少见。
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