McCullagh P
Aust J Exp Biol Med Sci. 1985 Jun;63 ( Pt 3):287-98. doi: 10.1038/icb.1985.32.
Normal syngeneic recipients rejected a substantial proportion of skin grafts following their retransplantation after a period of residence on tolerant allogeneic or normal semi-allogeneic hosts. Rejection was often atypical in its delayed onset and protracted course. Examination of the effect of a variety of manipulations of graft donors and of intermediate hosts revealed that active involvement of cells derived from both categories was required for the initiation of an allograft reaction after transfer to the ultimate, syngeneic recipient. Liability of retransplanted syngeneic skin grafts to rejection could be almost entirely abolished by their exposure to 300 rads irradiation before placement on the intermediate host. Skin from neonatally thymectomized donors or from rats specifically tolerant of the intermediate F1 hybrid host was much less liable to ultimate rejection than was skin from normal hosts. These experiments suggest that rejection of re-transplanted, syngeneic grafts may result from some form of activation of cells of the graft during its period on the intermediate host.
正常同基因受体在耐受的异基因或正常半异基因宿主上停留一段时间后再次移植皮肤移植物时，会排斥相当一部分移植物。排斥反应通常具有延迟发作和病程迁延的非典型特征。对移植物供体和中间宿主进行各种处理的效果进行检查后发现，在转移到最终的同基因受体后，引发同种异体移植反应需要来自这两类细胞的积极参与。重新移植的同基因皮肤移植物在置于中间宿主之前接受300拉德辐射，其被排斥的可能性几乎可以完全消除。新生期胸腺切除的供体的皮肤或对中间F1杂种宿主具有特异性耐受性的大鼠的皮肤，比正常宿主的皮肤更不容易被最终排斥。这些实验表明，重新移植的同基因移植物的排斥反应可能是由于移植物在中间宿主上停留期间某种形式的细胞活化所致。
