Viklický V, Holán V, Hasek M
Immunol Lett. 1981 Nov;3(5):289-91. doi: 10.1016/0165-2478(81)90007-9.
The organ distribution of 51Cr-labelled lymph node cells following transfer to syngeneic, allogeneic and specifically tolerant allogeneic recipients were compared. Neonatal induction of transplantation tolerance in several donor-recipient combinations involving different H-2 haplotypes had no effect on the reduction of homing into lymph nodes and the values of the homing did not differ from those of the untreated allogeneic recipients. In both cases, they amounted to 45-55% of the syngeneic controls. Even those neonatally treated animals, which had not been rendered tolerant at birth and rejected test skin grafts, were not capable of removing the transferred allogeneic cells by a typical immune elimination. The results indicate that animals recognize allogeneic cells, irrespective of whether or not they reject test skin grafts.
比较了51Cr标记的淋巴结细胞转移至同基因、异基因和特异性耐受的异基因受体后的器官分布情况。在涉及不同H-2单倍型的几种供体-受体组合中，新生期诱导移植耐受对归巢至淋巴结减少并无影响，且归巢值与未处理的异基因受体并无差异。在这两种情况下，其值均为同基因对照的45%-55%。即使是那些新生期处理过但出生时未产生耐受且排斥试验性皮肤移植物的动物，也无法通过典型的免疫清除作用清除转移的异基因细胞。结果表明，动物能够识别异基因细胞，无论它们是否排斥试验性皮肤移植物。
