Department of Surgery, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands.
Department of Surgery, Meander Medical Center, Amersfoort, The Netherlands.
PLoS One. 2024 Jul 24;19(7):e0307606. doi: 10.1371/journal.pone.0307606. eCollection 2024.
Anastomotic leakage is a major concern following total mesorectal excision for rectal cancer, affecting oncological outcomes, morbidity an treatment costs. Body composition has been suggested to influence anastomotic leakage rates. However, literature on how body composition impact anastomotic leakage rates is conflicting. This systematic review aims to evaluate the role of computed tomography derived body composition metrics on anastomotic leakage rates in rectal cancer patients.
Databases PubMed/MEDLINE, Cochrane Library, web of science, and EMBASE, will be systematically searched for papers from January 2010 onwards. Study selection, data collection and quality assessment will be independently performed by three research fellows. Outcomes described in three or more studies will be included in the meta-analysis. The Q-test and I2 statistic will be used to assess statistical heterogeneity between studies. Publication bias will be examined by visual inspection of funnel plots and quantified by Egger's test. Sensitivity analyses will be conducted to examine the robustness of the meta-analysis. Reporting of the findings will be in line with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines.
This systematic review will synthesize the current evidence and will identify knowledge gaps. Results of the systematic review will aid health care professional in pre-operative decision making and will be distributed through a peer-reviewed publication and presentation of results at international meetings.
PROSPERO protocol number: CRD42023471537.
直肠全系膜切除术后吻合口漏是直肠癌的一个主要关注点，影响肿瘤学结果、发病率和治疗费用。人体成分被认为会影响吻合口漏的发生率。然而，关于人体成分如何影响吻合口漏发生率的文献存在争议。本系统评价旨在评估 CT 衍生的人体成分指标在直肠癌患者吻合口漏发生率中的作用。
从 2010 年 1 月起，将通过数据库 PubMed/MEDLINE、Cochrane 图书馆、Web of Science 和 EMBASE 进行系统搜索。三名研究人员将独立进行研究选择、数据收集和质量评估。将纳入描述了三种或更多研究结果的结局进行荟萃分析。将使用 Q 检验和 I2 统计量来评估研究之间的统计学异质性。将通过视觉检查漏斗图和 Egger 检验来量化来评估发表偏倚。将进行敏感性分析以检查荟萃分析的稳健性。研究结果的报告将符合系统评价和荟萃分析的首选报告项目（PRISMA）指南。
本系统评价将综合当前的证据，并确定知识空白。系统评价的结果将有助于医疗保健专业人员在术前做出决策，并通过同行评议的出版物和在国际会议上展示结果来传播。
PROSPERO 方案编号：CRD42023471537。
