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饮食和水分限制会导致对抗生素耐药病原体的易感性增加。

Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens.

机构信息

Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Sci Adv. 2024 Jul 26;10(30):eadi7438. doi: 10.1126/sciadv.adi7438. Epub 2024 Jul 24.

DOI:10.1126/sciadv.adi7438
PMID:39047095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11268424/
Abstract

Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restriction (DWR) on susceptibility to multidrug-resistant pathogens is unknown. We report that DWR markedly increased susceptibility to systemic infection by ESKAPE pathogens. Using a murine bloodstream model of methicillin-resistant infection, we show that DWR leads to significantly increased mortality and morbidity. DWR causes increased bacterial burden, severe pathology, and increased numbers of phagocytes in the kidney. DWR appears to alter the functionality of these phagocytes and is therefore unable to control infection. Mechanistically, we show that DWR impairs the ability of macrophages to phagocytose multiple bacterial pathogens and efferocytose apoptotic neutrophils. Together, this work highlights the crucial impact that diet and hydration play in protecting against infection.

摘要

脱水和营养不良在医院环境中很常见，而且常常被漏诊。耐多药细菌感染导致每年有超过 35000 名医院获得性感染患者死亡。暂时的饮食和水限制（DWR）对耐多药病原体易感性的影响尚不清楚。我们报告称，DWR 显著增加了对 ESKAPE 病原体全身感染的易感性。使用耐甲氧西林金黄色葡萄球菌感染的小鼠血流模型，我们表明 DWR 导致死亡率和发病率显著增加。DWR 导致细菌负荷增加、严重的病理学和肾脏中吞噬细胞数量增加。DWR 似乎改变了这些吞噬细胞的功能，因此无法控制感染。从机制上讲，我们表明 DWR 削弱了巨噬细胞吞噬多种细菌病原体和吞噬凋亡中性粒细胞的能力。总之，这项工作强调了饮食和水合作用在预防感染方面的重要影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b10/11268424/cc9a840d88bb/sciadv.adi7438-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b10/11268424/cc9a840d88bb/sciadv.adi7438-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b10/11268424/625aae3f5ee1/sciadv.adi7438-f1.jpg
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