Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University - School of Medicine, Department of Surgery, Stanford, CA 94305, USA; Department of Biology/Chemistry, Osnabrück University, Osnabrück 49076, Germany; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht 3584CT, the Netherlands. Electronic address: https://twitter.com/@anto_tomasso.
Department of Biology/Chemistry, Osnabrück University, Osnabrück 49076, Germany; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht 3584CT, the Netherlands. Electronic address: https://twitter.com/@VDisela.
Curr Opin Genet Dev. 2024 Aug;87:102228. doi: 10.1016/j.gde.2024.102228. Epub 2024 Jul 22.
Understanding the cellular and molecular determinants of mammalian tissue regeneration and repair is crucial for developing effective therapies that restore tissue architecture and function. In this review, we focus on the cell types involved in scarless wound response and regeneration of spiny mice (Acomys). Comparative -omics approaches with scar-prone mammals have revealed species-specific peculiarities in cellular behavior during the divergent healing trajectories. We discuss the developing views on which cell types engage in restoring the architecture of spiny mouse tissues through a co-ordinated spatiotemporal response to injury. While yet at the beginning of understanding how cells interact in these fascinating animals to regenerate tissues, spiny mice hold great promise for scar prevention and anti-fibrotic treatments.
了解哺乳动物组织再生和修复的细胞和分子决定因素对于开发有效的治疗方法至关重要，这些方法可以恢复组织的结构和功能。在这篇综述中，我们专注于无疤痕伤口反应和多刺老鼠（Acomys）再生中涉及的细胞类型。与易留疤的哺乳动物进行的比较组学方法揭示了在不同的愈合轨迹中细胞行为的物种特异性特征。我们讨论了正在发展的观点，即哪些细胞类型通过对损伤的协调时空反应参与恢复多刺老鼠组织的结构。虽然我们还处于了解这些迷人的动物如何通过细胞相互作用来再生组织的早期阶段，但多刺老鼠在预防疤痕和抗纤维化治疗方面具有很大的潜力。
