UF Genetics Institute & Department of Biology, University of Florida, Gainesville, Florida.
Exp Dermatol. 2019 Apr;28(4):436-441. doi: 10.1111/exd.13847. Epub 2019 Jan 15.
Members of the Acomys genus, known as spiny mice, are unique among mammals in being perfectly capable of regenerating large areas of skin that have been removed. During this regenerative process hairs, sebaceous glands, erector pili muscles, adipocytes and the panniculus carnosus all regenerate and the dermis does not scar. We review here the processes that the epidermis and the individual components of the dermis undergo during spiny mouse regeneration as well as the molecules that have been identified as potentially important in regeneration. We then relate this to what has been proposed as playing a role in studies from the laboratory mouse, Mus musculus. Differences in the immune systems of spiny mice and laboratory mice are also highlighted as this is suggested to play a part not only in the perfect wound healing that embryos display but also in regeneration in lower vertebrates.
棘鼠属成员，被称为刺鼠，是唯一能够完美再生已切除的大面积皮肤的哺乳动物。在这个再生过程中，毛发、皮脂腺、竖毛肌、脂肪细胞和真皮下脂肪组织都会再生，真皮不会留下疤痕。在这里，我们回顾了棘鼠再生过程中表皮和真皮各个成分所经历的过程，以及被确定为在再生中可能具有重要作用的分子。然后，我们将其与实验室小鼠 Mus musculus 研究中提出的可能发挥作用的分子联系起来。棘鼠和实验室小鼠免疫系统的差异也被强调，因为这不仅在胚胎的完美伤口愈合中发挥作用，而且在较低等脊椎动物的再生中也发挥作用。
