The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6195001 Tel Aviv, Israel. Electronic address: https://twitter.com/@Nofar_MalkaTun.
The Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 6195001 Tel Aviv, Israel.
Curr Opin Genet Dev. 2024 Aug;87:102232. doi: 10.1016/j.gde.2024.102232. Epub 2024 Jul 22.
The epitranscriptome encompasses over 170 post-transcriptional modifications found in various RNA species. RNA modifications play pivotal roles in regulating gene expression by shaping RNA structure and function, implicating the epitranscriptome in diverse biological processes, including pathology progression. This review focuses on research elucidating the roles of the epitranscriptome in cancer metastasis. Metastasis, a primary cause of solid tumor patient mortality, involves a multistep process whereby tumor cells migrate from a primary tumor to distant secondary organs. We discuss RNA modifications found on rRNA, tRNA, and mRNA, highlighting their roles in different stages of metastasis. Understanding mechanisms by which modifications regulate molecular and cellular processes during metastasis is crucial for leveraging epitranscriptomic signatures in cancer diagnosis and treatment.
表观转录组包含了各种 RNA 分子中超过 170 种转录后修饰。RNA 修饰通过塑造 RNA 结构和功能在调控基因表达中起着关键作用，这意味着表观转录组参与了多种生物学过程，包括疾病进展。本篇综述聚焦于研究表观转录组在癌症转移中的作用。转移是实体瘤患者死亡的主要原因，它涉及一个多步骤的过程，其中肿瘤细胞从原发性肿瘤迁移到远处的继发性器官。我们讨论了在 rRNA、tRNA 和 mRNA 上发现的 RNA 修饰，强调了它们在转移的不同阶段中的作用。了解修饰如何在转移过程中调节分子和细胞过程的机制，对于利用表观转录组特征进行癌症诊断和治疗至关重要。
