Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Senior Department of Gastroenterology, the First Medical Center of PLA General Hospital, Beijing, 100071, China.
Int J Colorectal Dis. 2024 Jul 24;39(1):118. doi: 10.1007/s00384-024-04694-9.
The fragmentation of polyps affects complete resection confirmation. The primary aim of this study was to assess the feasibility of a novel polyp retrieval bag for reducing the fragmentation rate of colon polyps.
Patients with a 5-15 mm colon polyp were recruited and randomized into two groups at a 1:1 ratio. After polyp resection, polyps obtained from patients in the treatment group were extracted via a novel polyp retrieval bag without traversing the instrument channel, whereas polyps obtained from patients in the control group were collected through the instrument channel, attaching the polyp trap to the instrument channel port, and applying suction.
From January to July 2022, 225 patients were assessed for eligibility. The study participants included 204 patients, and seven patients whose samples were not retrieved were excluded. Polyp fragmentation was significantly lower in the treatment group than in the control group (3.0% [3/100] vs. 17.5% [17/97], P = 0.001). The retrieval failure rates in the treatment group and control group were not significantly different (2.0% [2/102] vs. 4.9% [5/102], P = 0.442). There were fewer colonoscope insertions in the treatment group than in the control group (102 vs. 110), but a significant difference was not present (P = 0.065). No significant adverse events were observed during the follow-up.
This study demonstrated that the polyp retrieval bag was safe and feasible for reducing the fragmentation rate of retrieved polyps.
The study was registered at ClinicalTrials.gov (NCT05189912, 1/12/2021).
息肉的碎裂会影响完全切除的确认。本研究的主要目的是评估一种新型息肉回收袋减少结肠息肉碎裂率的可行性。
招募了直径为 5-15mm 的结肠息肉患者，并以 1:1 的比例随机分为两组。息肉切除后，治疗组的息肉通过新型息肉回收袋提取，无需穿过器械通道，而对照组的息肉则通过器械通道收集，将息肉捕捉器连接到器械通道端口，并施加吸力。
2022 年 1 月至 7 月，对 225 名患者进行了资格评估。研究参与者包括 204 名患者，7 名未提取样本的患者被排除。治疗组的息肉碎裂率明显低于对照组（3.0%[3/100]比 17.5%[17/97]，P=0.001）。治疗组和对照组的回收失败率无显著差异（2.0%[2/102]比 4.9%[5/102]，P=0.442）。治疗组的结肠镜插入次数少于对照组（102 次比 110 次），但差异无统计学意义（P=0.065）。在随访期间未观察到严重不良事件。
本研究表明，息肉回收袋安全且可行，可降低回收息肉的碎裂率。
该研究在 ClinicalTrials.gov 注册（NCT05189912，2021 年 1 月 12 日）。
