Dassin E
Nouv Rev Fr Hematol (1978). 1979;21(2):209-18.
Under normal conditions the circulating platelet mass is remarkably constant, which suggested early on that a negative feedback mechanism was involved in the control of thrombocytopoiesis. Furthermore, plasma or serum from thrombocytopenic animals or humans has been reported to stimulate platelet production when injected into laboratory animals, thus suggesting that it contained a thrombopoietin(s). During the past decade, the biochemistry and physiology of thrombopoietin have been studied. However, it is not now well established that thrombopoietin is a glycoprotein produced, at least in part, by the kidney. Moreover, particular attention may be directed to its machanism of action.
在正常情况下，循环血小板量显著恒定，这在早期提示血小板生成的控制涉及一种负反馈机制。此外，据报道，将血小板减少的动物或人的血浆或血清注入实验动物后可刺激血小板生成，因此提示其中含有血小板生成素。在过去十年中，对血小板生成素的生物化学和生理学进行了研究。然而，目前尚不能确定血小板生成素是一种至少部分由肾脏产生的糖蛋白。此外，可能需要特别关注其作用机制。
