McDonald T P
University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071.
Exp Hematol. 1988 Mar;16(3):201-5.
The existence of thrombopoietin, a hormone that controls blood platelet production, was proposed almost 30 years ago, but it has been only during the past 10-15 years that sufficient knowledge was obtained to establish that this humoral factor is a major in vivo controlling factor of thrombocytopoiesis. This concise review attempts to summarize the hormone's history, background, effects on megakaryocytes and platelet production, sources, and purification and characterization, along with the current status of research on this hematopoietic-stimulating factor. New evidence for biological and chemical similarities of thrombopoietin from thrombocytopenic animals and human embryonic kidney cells is also presented.
血小板生成素作为一种控制血小板生成的激素，其存在早在近30年前就已被提出，但直到过去10到15年才获得足够的知识来确定这种体液因子是体内血小板生成的主要控制因子。这篇简要综述试图总结该激素的历史、背景、对巨核细胞和血小板生成的影响、来源、纯化与特性，以及对这种造血刺激因子的当前研究状况。文中还介绍了来自血小板减少动物和人胚肾细胞的血小板生成素在生物学和化学上具有相似性的新证据。
