• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

包裹在透明质酸纳米颗粒中的磷酸康普瑞汀A4对口腔鳞状细胞癌具有高度细胞毒性。

Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma.

作者信息

Sun Chuanxi, Zhou Ziqi, Liu Fangqiang, Li Hong, Liu Zhe

机构信息

Department of Orthodontics, The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.

Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province, China.

出版信息

Arch Med Sci. 2024 Jun 30;20(3):1022-1028. doi: 10.5114/aoms/189535. eCollection 2024.

DOI:10.5114/aoms/189535
PMID:39050147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11264095/
Abstract

INTRODUCTION

To investigate the toxicity of combretastatin A4 phosphate (CA4P) hyaluronic acid (HA) gel nanoparticles (HA-CA4P-NPs) in OSCC (oral squamous cell carcinoma).

METHODS

Toxicity was investigated using fluorescence microscopy, MTT assay, flow cytometry, and OSCC xenograft mouse models.

RESULTS

Compared with CA4P, HA-CA4P-NPs generated nearly 10 times more fluorescence in OSCC cells. Cytotoxicity assays showed that HACA4P-NPs were more toxic to SCC-4 cells but not to HNECs. Remarkable necrosis was induced in SCC-4 cells after exposure to HA-CA4P-NPs, and related proteins were upregulated. Furthermore, HA-CA4P-NPs significantly reduced the tumour size.

CONCLUSIONS

HA-CA4P-NPs improved drug release and delivery, and increased cytotoxicity to cancer cells.

摘要

引言

研究磷酸考布他汀A4（CA4P）透明质酸（HA）凝胶纳米颗粒（HA-CA4P-NPs）对口腔鳞状细胞癌（OSCC）的毒性。

方法

使用荧光显微镜、MTT法、流式细胞术和OSCC异种移植小鼠模型研究毒性。

结果

与CA4P相比，HA-CA4P-NPs在OSCC细胞中产生的荧光几乎多10倍。细胞毒性试验表明，HA-CA4P-NPs对SCC-4细胞毒性更大，但对人正常口腔角质形成细胞（HNECs）无毒性。暴露于HA-CA4P-NPs后，SCC-4细胞中出现明显坏死，相关蛋白上调。此外，HA-CA4P-NPs显著减小了肿瘤大小。

结论

HA-CA4P-NPs改善了药物释放和递送，并增加了对癌细胞的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256d/11264095/be5092adcb3c/AMS-20-3-189535-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256d/11264095/be5092adcb3c/AMS-20-3-189535-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256d/11264095/be5092adcb3c/AMS-20-3-189535-g001a.jpg

相似文献

1
Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma.包裹在透明质酸纳米颗粒中的磷酸康普瑞汀A4对口腔鳞状细胞癌具有高度细胞毒性。
Arch Med Sci. 2024 Jun 30;20(3):1022-1028. doi: 10.5114/aoms/189535. eCollection 2024.
2
Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles With Improved Inhibition Effect Toward S180 Tumors.水溶性康普瑞汀 A4 磷酸盐经复合纳米粒口服给药，增强对 S180 肿瘤的抑制作用。
J Pharm Sci. 2017 Oct;106(10):3076-3083. doi: 10.1016/j.xphs.2017.05.031. Epub 2017 Jun 13.
3
A single dose of intravenous combretastatin A4-phosphate is reasonably well tolerated and significantly reduces tumour vascularization in canine spontaneous cancers.单剂量静脉注射磷酸考布他汀A4耐受性良好，并能显著减少犬自发性癌症中的肿瘤血管生成。
Vet Comp Oncol. 2018 Dec;16(4):467-477. doi: 10.1111/vco.12402. Epub 2018 May 24.
4
Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck.放疗联合 Combretastatin A4-磷酸治疗非小细胞肺癌、前列腺腺癌和头颈部鳞状细胞癌的 Ib 期临床试验。
Ann Oncol. 2012 Jan;23(1):231-237. doi: 10.1093/annonc/mdr332. Epub 2011 Jul 15.
5
Concentration-Induced J-Aggregate Formation Causes a Biphasic Change in the Release of trans-Combretastatin A4 Disodium Phosphate from Archaeosomes and the Subsequent Cytotoxicity on Mammary Cancer Cells.浓度诱导的J-聚集体形成导致磷酸反式康普瑞他汀A4二钠从古脂质体释放的双相变化以及随后对乳腺癌细胞的细胞毒性。
Mol Pharm. 2015 Oct 5;12(10):3724-34. doi: 10.1021/acs.molpharmaceut.5b00500. Epub 2015 Sep 22.
6
Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors.磷酸考布他汀A4对人间变性甲状腺癌细胞系和异种移植肿瘤具有主要抗肿瘤活性。
Thyroid. 2002 Dec;12(12):1063-70. doi: 10.1089/105072502321085153.
7
Liver-targeted liposomes for codelivery of curcumin and combretastatin A4 phosphate: preparation, characterization, and antitumor effects.载姜黄素和考布他汀 A4 磷酸的肝靶向脂质体的制备、表征及抗肿瘤作用。
Int J Nanomedicine. 2019 Mar 8;14:1789-1804. doi: 10.2147/IJN.S188971. eCollection 2019.
8
Co-Encapsulation of Combretastatin-A4 Phosphate and Doxorubicin in Polymersomes for Synergistic Therapy of Nasopharyngeal Epidermal Carcinoma.磷酸考布他汀A4与阿霉素共包裹于聚合物囊泡用于鼻咽癌协同治疗
J Biomed Nanotechnol. 2015 Jun;11(6):997-1006. doi: 10.1166/jbn.2015.2010.
9
Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model.包括磷酸考布他汀A4和紫杉醇在内的联合化疗在裸鼠异种移植模型中对间变性甲状腺癌有效。
J Clin Endocrinol Metab. 2007 Aug;92(8):2902-9. doi: 10.1210/jc.2007-0027. Epub 2007 Jun 5.
10
Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma.低剂量磷酸考布他汀A4增强肿瘤宿主对实验性结肠癌的免疫反应。
Clin Cancer Res. 2006 Aug 1;12(15):4714-9. doi: 10.1158/1078-0432.CCR-05-2807.

本文引用的文献

1
Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model.游离姜黄素和纳米姜黄素对动物模型中化学诱导肝癌的影响。
Arch Med Sci. 2020 Mar 17;17(1):218-227. doi: 10.5114/aoms.2020.93739. eCollection 2021.
2
Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma.CD168 过表达与口腔鳞状细胞癌的预后不良相关。
Oral Dis. 2022 Mar;28(2):364-372. doi: 10.1111/odi.13766. Epub 2021 Jan 15.
3
Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway.
糖皮质激素通过ROS/JNK/c-Jun途径诱导大鼠股骨头坏死。
FEBS Open Bio. 2021 Jan;11(1):312-321. doi: 10.1002/2211-5463.13037. Epub 2020 Nov 30.
4
Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy.基于透明质酸的多功能纳米载体用于联合癌症治疗。
Curr Top Med Chem. 2021;21(2):126-139. doi: 10.2174/1568026620666200922113846.
5
The first study on therapeutic efficacies of a vascular disrupting agent CA4P among primary hepatocellular carcinomas with a full spectrum of differentiation and vascularity: Correlation of MRI-microangiography-histopathology in rats.首项关于血管破坏剂 CA4P 在具有全分化和血管性的原发性肝细胞癌中的治疗功效的研究：大鼠 MRI 微血管造影-组织病理学相关性。
Int J Cancer. 2018 Oct 1;143(7):1817-1828. doi: 10.1002/ijc.31567. Epub 2018 Jul 3.
6
Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization.癌症纳米医学的合理设计：纳米特性的整合与同步。
Adv Mater. 2017 Apr;29(14). doi: 10.1002/adma.201606628. Epub 2017 Feb 24.
7
Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy.口腔鳞状细胞癌：当前的治疗策略以及基于纳米技术的预防和治疗方法
Crit Rev Ther Drug Carrier Syst. 2016;33(4):363-400. doi: 10.1615/CritRevTherDrugCarrierSyst.2016016272.
8
Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery.亲水性烟酰胺与纳米颗粒联合用于增强他克莫司经皮递送
Int J Nanomedicine. 2016 Aug 19;11:4037-50. doi: 10.2147/IJN.S108545. eCollection 2016.
9
Bioinspired synthesis of magnetite nanoparticles.仿生合成磁铁矿纳米粒子。
Chem Soc Rev. 2016 Sep 21;45(18):5085-106. doi: 10.1039/c6cs00432f. Epub 2016 Jul 7.
10
Future of nanotherapeutics: Targeting the cellular sub-organelles.纳米治疗学的未来：靶向细胞亚细胞器。
Biomaterials. 2016 Aug;97:10-21. doi: 10.1016/j.biomaterials.2016.04.026. Epub 2016 Apr 26.