脂蛋白(a)与2型糖尿病之间的关联：一项孟德尔随机化研究。
Association between Lp(a) and T2D: a Mendelian randomization study.
作者信息
Goławski Marcin, Lejawa Mateusz, Banach Maciej, Jóźwiak Jacek, Gierlotka Marek, Osadnik Tadeusz
机构信息
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Lodz, Poland.
出版信息
Arch Med Sci. 2024 Apr 20;20(3):1002-1005. doi: 10.5114/aoms/187774. eCollection 2024.
INTRODUCTION
Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed.
METHODS
A two-sample MR analysis was conducted. Data were obtained from UK Biobank and FinnGen consortia. Primary analysis was based on an inverse-variance-weighted mean (IVM) approach.
RESULTS
No statistically significant association between the genetically predicted levels of Lp(a) and T2D was detected ( = 0.362) in IVM analysis involving data of 563,420 patients.
CONCLUSIONS
Genetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D.
引言
已观察到血液脂蛋白(a)（Lp(a)）水平与2型糖尿病（T2D）呈负相关。在这项孟德尔随机化（MR）研究中，评估了基因预测的Lp(a)对T2D的因果影响。
方法
进行了两样本MR分析。数据来自英国生物银行和芬兰基因组联盟。主要分析基于逆方差加权均值（IVM）方法。
结果
在涉及563420名患者数据的IVM分析中，未检测到基因预测的Lp(a)水平与T2D之间存在统计学显著关联（ = 0.362）。
结论
基因预测的Lp(a)浓度似乎与T2D风险无因果关系。
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