植物大麻素和内源性大麻素对中枢神经系统和外周Nrf2活性的影响。
The Effect of Phytocannabinoids and Endocannabinoids on Nrf2 Activity in the Central Nervous System and Periphery.
作者信息
Marini Pietro, Maccarrone Mauro, Saso Luciano, Tucci Paolo
机构信息
Institute of Education in Healthcare and Medical Sciences, Foresterhill Campus, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio snc, Coppito, 67100 L'Aquila, Italy.
出版信息
Neurol Int. 2024 Jul 18;16(4):776-789. doi: 10.3390/neurolint16040057.
The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in a variety of models of peripheral illnesses, with little clarification on their interaction within the central nervous system (CNS). In this context, evidence suggests that the Nrf2-pCBs/eCBS interaction is relevant in modulating peroxidation processes and the antioxidant system. Nrf2, one of the regulators of cellular redox homeostasis, appears to have a protective role toward damaging insults to neurons and glia by enhancing those genes involved in the regulation of homeostatic processes. Specifically in microglia and macroglia cells, Nrf2 can be activated, and its signaling pathway modulated, by both pCBs and eCBs. However, the precise effects of pCBs and eCBs on the Nrf2 signaling pathway are not completely elucidated yet, making their potential clinical employment still not fully understood.
在多种外周疾病模型中，人们已经研究了核因子红细胞2相关因子2（Nrf2）与植物大麻素/内源性大麻素（pCBs/eCBs）之间的关系，但对于它们在中枢神经系统（CNS）中的相互作用却鲜有阐明。在这种情况下，有证据表明Nrf2-pCBs/eCBs相互作用在调节过氧化过程和抗氧化系统方面具有相关性。Nrf2是细胞氧化还原稳态的调节因子之一，通过增强参与稳态过程调节的那些基因，似乎对神经元和神经胶质细胞的损伤性刺激具有保护作用。具体而言，在小胶质细胞和大胶质细胞中，pCBs和eCBs均可激活Nrf2并调节其信号通路。然而，pCBs和eCBs对Nrf2信号通路的确切影响尚未完全阐明，这使得它们在临床上的潜在应用仍未得到充分理解。
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