Rybarczyk Anna, Majchrzak-Celińska Aleksandra, Krajka-Kuźniak Violetta
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, Poland.
Antioxidants (Basel). 2023 Nov 28;12(12):2052. doi: 10.3390/antiox12122052.
The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, regulates the cellular defense against oxidative stress and inflammation, making it a promising cancer prevention and treatment target. Cannabinoids have demonstrated anti-tumor and anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased oxidative stress following exposure to anti-cancer therapy prompts cancer cells to activate antioxidant mechanisms. This indicates the dual effect of Nrf2 in cancer cells-influencing proliferation and apoptotic processes and protecting against the toxicity of anti-cancer therapy. Therefore, understanding the complex role of cannabinoids in modulating Nrf2 might shed light on its potential implementation as an anti-cancer support. In this review, we aim to highlight the impact of cannabinoids on Nrf2-related factors, with a focus on cancer prevention and treatment. Additionally, we have presented the results of several research studies that combined cannabidiol (CBD) with other compounds targeting Nrf2. Further studies should be directed toward exploring the anti-inflammatory effects of cannabinoids in the context of cancer prevention and therapy.
癌症的发生和发展与细胞增殖和存活所涉及的多种信号通路失调有关，同时也与氧化还原平衡、免疫反应和炎症功能障碍有关。主要的抗氧化信号通路，即核因子红细胞2相关因子2（Nrf2）信号通路，可调节细胞对氧化应激和炎症的防御，使其成为一个有前景的癌症预防和治疗靶点。大麻素已显示出抗肿瘤和抗炎特性，可影响包括Nrf2在内的信号通路。接触抗癌治疗后氧化应激增加会促使癌细胞激活抗氧化机制。这表明Nrf2在癌细胞中具有双重作用——影响增殖和凋亡过程，并对抗癌治疗的毒性起到保护作用。因此，了解大麻素在调节Nrf2中的复杂作用可能有助于揭示其作为抗癌辅助手段的潜在应用价值。在本综述中，我们旨在强调大麻素对Nrf2相关因子的影响，重点关注癌症的预防和治疗。此外，我们还展示了几项将大麻二酚（CBD）与其他靶向Nrf2的化合物联合使用的研究结果。未来的研究应致力于探索大麻素在癌症预防和治疗背景下的抗炎作用。
