Bužančić Iva, Balen Mislav, Arbanas Dahna, Falamić Slaven, Fehir Šola Katarina, Galić Skoko Ana, Momčilović Mirna, Orbanić Ante, Tatarević Alena, Ortner Hadžiabdić Maja
City Pharmacies Zagreb, 10 000 Zagreb, Croatia.
Faculty of Pharmacy and Biochemistry, University of Zagreb, 10 000 Zagreb, Croatia.
Pharmacy (Basel). 2024 Jul 18;12(4):113. doi: 10.3390/pharmacy12040113.
Despite the availability of various tools for measuring medication adherence, efficiently identifying non-adherence levels and reasons at the point of care remains challenging. Existing tools often lack the ease of use needed for practical clinical application. This study aimed to develop and validate a user-friendly tool to provide healthcare professionals with a concise yet comprehensive means of identifying adherence behaviors. The methodology consisted of two phases: tool items were first developed using the nominal group technique with healthcare professionals, followed by a cross-sectional pilot study involving community-dwelling adults in Croatia. Validation analysis indicated acceptable face and content validity and satisfactory criterion validity, with Attitudes towards meDication adHErence self-Reported questionnairE (ADHERE-7) scores correlating with both the self-reported five-item Medication Adherence Report Scale (MARS-5 tool) (ρ = 0.765; < 0.001) and an objective measure of the proportion of days covered (PDC) from pharmacy prescription claims data (G = 0.586; = 0.015). Construct validity revealed three factors: Aversion, Comfort, and Practical Non-Adherence, with Cronbach's alpha values of 0.617 for Aversion and 0.714 for Comfort Non-Adherence. The mean total score for ADHERE-7 was 26.27 ± 2.41 (range 17 to 28). This robust validation process confirms the ADHERE-7 tool as a reliable instrument for assessing medication adherence, addressing aversion, comfort, practical issues, and both intentional and unintentional nonadherence.
尽管有各种用于测量药物依从性的工具，但在护理点有效识别不依从水平和原因仍然具有挑战性。现有工具往往缺乏实际临床应用所需的易用性。本研究旨在开发并验证一种用户友好型工具，为医疗保健专业人员提供一种简洁而全面的识别依从行为的方法。该方法包括两个阶段：首先使用名义组技术与医疗保健专业人员一起开发工具项目，然后在克罗地亚进行一项涉及社区居住成年人的横断面试点研究。验证分析表明该工具具有可接受的表面效度和内容效度以及令人满意的效标效度，药物依从性自我报告问卷（ADHERE-7）得分与自我报告的五项药物依从性报告量表（MARS-5工具）（ρ = 0.765；<0.001）以及药房处方索赔数据中覆盖天数比例（PDC）的客观测量值（G = 0.586； = 0.015）均相关。结构效度揭示了三个因素：厌恶、舒适度和实际不依从，其中厌恶因素的Cronbach's alpha值为0.617，舒适度不依从因素的Cronbach's alpha值为0.714。ADHERE-7的平均总分是26.27±2.41（范围为17至28）。这一稳健的验证过程证实了ADHERE-7工具是评估药物依从性、解决厌恶情绪、舒适度、实际问题以及有意和无意不依从情况的可靠工具。
