Lepage Martin, Guimond Synthia, Raedler Thomas, McNeely Heather E, Ungar Thomas, Margolese Howard C, Best Michael
Department of Psychiatry, Douglas Research Centre, McGill University, Verdun, Quebec, Canada.
Department of Psychiatry, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
Can J Psychiatry. 2025 Feb;70(2):85-97. doi: 10.1177/07067437241261928. Epub 2024 Jul 25.
Schizophrenia spectrum disorders (SSDs) are a group of psychiatric disorders characterized by positive and negative symptoms as well as cognitive impairment that can significantly affect daily functioning.
We reviewed evidence-based strategies for improving cognitive function in patients with SSDs, focusing on the Canadian landscape.
Although antipsychotic medications can address the positive symptoms of SSDs, cognitive symptoms often persist, causing functional impairment and reduced quality of life. Moreover, cognitive function in patients with SSDs is infrequently assessed in clinical practice, and evidence-based recommendations for addressing cognitive impairment in people living with schizophrenia are limited. While cognitive remediation (CR) can improve several domains of cognitive function, most individuals with SSDs are currently not offered such an intervention. While the development of implementation strategies for CR is underway, available and emerging pharmacological treatments may help overcome the limited capacity for psychosocial approaches. Furthermore, combining pharmacological with non-pharmacological interventions may improve outcomes compared to pharmacotherapy or CR alone.
This review highlights the challenges and discusses the potential solutions related to the assessment and management of cognitive impairment to help mental health-care practitioners better manage cognitive impairment and improve daily functioning in individuals with SSDs.
Improving Thinking Skills in People With Schizophrenia: A Focus on Canada.
精神分裂症谱系障碍(SSDs)是一组精神疾病,其特征为存在阳性和阴性症状以及认知障碍,这些会显著影响日常功能。
我们回顾了改善精神分裂症谱系障碍患者认知功能的循证策略,重点关注加拿大的情况。
尽管抗精神病药物可以解决精神分裂症谱系障碍的阳性症状,但认知症状往往持续存在,导致功能受损和生活质量下降。此外,在临床实践中,精神分裂症谱系障碍患者的认知功能很少得到评估,且针对精神分裂症患者认知障碍的循证建议有限。虽然认知康复(CR)可以改善认知功能的多个领域,但目前大多数精神分裂症谱系障碍患者并未接受此类干预。虽然认知康复实施策略的开发正在进行中,但现有的和新出现的药物治疗可能有助于克服心理社会方法的局限性。此外,与单独使用药物治疗或认知康复相比,将药物治疗与非药物干预相结合可能会改善治疗效果。
本综述强调了相关挑战,并讨论了与认知障碍评估和管理相关的潜在解决方案,以帮助心理健康从业者更好地管理认知障碍,改善精神分裂症谱系障碍患者的日常功能。
提高精神分裂症患者的思维能力:以加拿大为重点。