Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
School of Science, Shandong Jianzhu University, Jinan, China.
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241263197. doi: 10.1177/15330338241263197.
Ultrasound examination is becoming the most popular medical imaging modality because of its low cost and high safety profile. Ultrasound contrast agents enhance the scattering of sound waves, which can improve the clarity and resolution of images. Nanoparticle Ultrasound contrast agents have the characteristics of a large specific surface area and a modifiable surface, which can increase drug loading capacity, prolong circulation time, and enable drug enrichment in specific organs or tissues. This leads to improved therapeutic effects and reducing toxic and side effects. Compared with traditional ultrasound contrast agents, Nano-ultrasound contrast agents overcome the limitation of imaging solely within blood vessels and facilitate imaging within tumor tissues, thereby extending the duration of enhanced imaging. Sonodynamic therapy is an emerging treatment method that has been developed rapidly in recent years, which has the advantages of noninvasive, high spatial and temporal resolution, and low toxicity and side effects. Sonodynamic therapy utilizes a sonosensitizer that, when excited by ultrasound at the tumor site, produces toxic reactive oxygen species, inducing apoptosis or necrosis in tumor cells. Ultrasound-guided sonodynamic therapy allows for real-time observation of lesions, is convenient and flexible, and is free of radiation exposure. With the use of nanomaterials as carriers, ultrasound-guided sonodynamic therapy has made significant strides. This study categorizes and summarizes the current research on acoustic sensitizer carrier materials, including carbon-based, silicon-based, peptide-based, iron-based, metal-organic frameworks, polymers, and liposomes. It concludes by highlighting the current challenges in the integration of ultrasound imaging with sonodynamic therapy and suggests future directions for clinical application development.
超声检查因其成本低、安全性高而成为最受欢迎的医学成像方式。超声造影剂增强了声波的散射，从而提高了图像的清晰度和分辨率。纳米粒子超声造影剂具有比表面积大、表面可修饰的特点，可以增加药物载药量、延长循环时间，并使药物在特定器官或组织中富集。这导致治疗效果的提高和毒性及副作用的减少。与传统的超声造影剂相比，纳米超声造影剂克服了仅在血管内成像的限制，有利于在肿瘤组织内成像，从而延长了增强成像的持续时间。声动力学治疗是一种近年来迅速发展起来的新兴治疗方法，具有非侵入性、高时空分辨率、低毒性和副作用的优点。声动力学治疗利用声敏剂，当在肿瘤部位被超声激发时，会产生有毒的活性氧物质，诱导肿瘤细胞凋亡或坏死。超声引导的声动力学治疗可以实时观察病变，方便灵活，并且没有辐射暴露。纳米材料作为载体，超声引导的声动力学治疗取得了重大进展。本研究对声敏剂载体材料的研究进行了分类和总结，包括碳基、硅基、肽基、铁基、金属有机骨架、聚合物和脂质体。最后，本文强调了将超声成像与声动力学治疗相结合的当前挑战，并提出了未来临床应用发展的方向。
