Basu Lisa, Bhowmik Biplab, Pal Aparajita, Roy Priya, Dey Bipasa, Mondal Riya, Roy Chayanika, Halder Labani
Department of Zoology, Diamond Harbour Women's University, Sarisha, South 24 Parganas, West Bengal, India.
J Vector Borne Dis. 2024 Jul 12. doi: 10.4103/JVBD.JVBD_72_24.
From ancient times until 21st century, Malaria has remained a fatal disease. It causes death in many poor and developing countries. Excluding vector control, Antimalarial drugs are the most reliable and effective weapon to tackle this severe disease. The emergence of antimalarial drug resistance in Plasmodium spp. becomes a barrier in Malaria elimination program as there has been no effective antimalarial vaccine till today. Apart from artemisinin, most of the antimalarial drugs have become resistant against malaria at present. Although, reduced efficacy of artemisinin-based combination therapy (ACT) has also been reported from southeast regions of Asia. Mutation of some genes within the parasite play a vital role in this drug resistance. Therefore, malaria is still a prime threat to human death and an unsolved problem. Newly emerging approaches like, vaccine development, plants based antimalarial drugs, nanoparticles, next generation antimalarial drugs should be taken & supported. In addition to that, public awareness is much needed for understanding the fatality of the disease and for encouraging self-protection and early treatment.
从古代到21世纪，疟疾一直是一种致命疾病。它在许多贫穷和发展中国家导致死亡。除了病媒控制外，抗疟药物是应对这种严重疾病最可靠、最有效的武器。疟原虫属中抗疟药物耐药性的出现成为疟疾消除计划的一个障碍，因为直到今天还没有有效的抗疟疫苗。除青蒿素外，目前大多数抗疟药物已对疟疾产生耐药性。尽管在亚洲东南部地区也报告了以青蒿素为基础的联合疗法（ACT）疗效降低的情况。寄生虫体内某些基因的突变在这种耐药性中起着至关重要的作用。因此，疟疾仍然是对人类死亡的主要威胁和一个未解决的问题。应该采用并支持新出现的方法，如疫苗研发、植物源抗疟药物、纳米颗粒、新一代抗疟药物。除此之外，非常需要提高公众意识，以了解该疾病的致命性，并鼓励自我保护和早期治疗。
