Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Eur J Nutr. 2024 Oct;63(7):2779-2788. doi: 10.1007/s00394-024-03471-2. Epub 2024 Jul 25.
The association between vitamin E and the risk of kidney disease is well documented in observational studies, but the role of vitamin E in kidney disease remain inconclusive. Here, we evaluated the causal effect of vitamin E on the risk of multiple kidney diseases, including chronic kidney disease, membranous nephropathy, diabetic nephropathy, IgA nephropathy, and dialysis.
We conducted a two-sample Mendelian randomization analysis from large-scale trans-ancestry genome-wide association studies to determine whether there was a significant causal relationship between vitamin E and multiple kidney diseases in European, American, and Asian ancestry. Instrumental genetic variants associated with vitamin E were selected, and summary statistic-based methods of inverse variance weighted, MR Egger, weighted median, simple mode, and weighted mode methods were conducted. Pleiotropy and sensitivity were assessed.
We obtained 87 instrumental genetic variants in European ancestry and found no causal relationship between vitamin E and chronic kidney disease, membranous nephropathy, diabetic nephropathy, IgA nephropathy, and dialysis with no heterogeneity and pleiotropy. We obtained 18 instrumental genetic variants in Asian ancestry and vitamin E had no causal relationship with membranous nephropathy, diabetic nephropathy, and IgA nephropathy with no heterogeneity and pleiotropy. In African ancestry, 25 instrumental genetic variants were obtained and no causal relationship was identified with no heterogeneity and pleiotropy.
Our study first suggested plausible non-causal associations between vitamin E and multiple kidney diseases among different ancestry.
维生素 E 与肾脏疾病风险之间的关联在观察性研究中已有充分记录，但维生素 E 在肾脏疾病中的作用仍不确定。在这里，我们评估了维生素 E 对多种肾脏疾病（包括慢性肾脏病、膜性肾病、糖尿病肾病、IgA 肾病和透析）风险的因果作用。
我们从大规模跨种族全基因组关联研究中进行了两样本 Mendelian 随机化分析，以确定维生素 E 与欧洲、美洲和亚洲血统的多种肾脏疾病之间是否存在显著的因果关系。选择与维生素 E 相关的工具性遗传变异，并进行基于汇总统计的逆方差加权、MR Egger、加权中位数、简单模式和加权模式方法。评估了多效性和敏感性。
我们在欧洲血统中获得了 87 个工具性遗传变异，没有发现维生素 E 与慢性肾脏病、膜性肾病、糖尿病肾病、IgA 肾病和透析之间存在因果关系，没有异质性和多效性。我们在亚洲血统中获得了 18 个工具性遗传变异，没有发现维生素 E 与膜性肾病、糖尿病肾病和 IgA 肾病之间存在因果关系，没有异质性和多效性。在非洲血统中，我们获得了 25 个工具性遗传变异，没有发现与异质性和多效性无关的因果关系。
我们的研究首次表明，在不同血统中，维生素 E 与多种肾脏疾病之间存在合理的非因果关联。
