Department of Nephrology, The Second Hospital of Jilin University, 218 Zi-Qiang Street, Changchun, Jilin, 130000, China.
Mol Nutr Food Res. 2023 Nov;67(22):e2300269. doi: 10.1002/mnfr.202300269. Epub 2023 Sep 19.
To summarize the effect of vitamin E-coated dialyzer membranes (VEMs) treatment or oral vitamin E intake on antioxidant molecules, such as superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant level in patients receiving dialysis.
A literature search of PubMed, Embase, CNKI, and the Cochrane Library databases is performed from inception to July 1, 2023, with no language nor country restrictions. Twenty-four experimental studies involving 512 patients undergoing dialysis are selected for meta-analysis. The levels of antioxidant markers in the blood of patients receiving hemodialysis (HD) improve with long-term VEMs treatment (p = 0.016). According to the findings of each antioxidant index, there is a significant increase in the levels of erythrocyte-derived SOD (p = 0.047), CAT (p = 0.029), and plasma-derived total antioxidant level (p < 0.001). The antioxidant marker levels in patients receiving HD are significantly increased by oral vitamin E intake (p < 0.001). Erythrocyte-derived SOD (p = 0.003), GPX (p < 0.001), and CAT (p = 0.001) substantially improves after 2-6 months of intervention with oral vitamin E preparation. The antioxidant index of patients receiving peritoneal dialysis (PD) is unaffected by oral vitamin E treatment (p = 0.945).
Vitamin E therapy has a favorable effect on the retention of antioxidant compounds in patients undergoing dialysis.
总结维生素 E 涂层透析器膜（VEM）治疗或口服维生素 E 对接受透析患者的抗氧化分子（如超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）、过氧化氢酶（CAT）和总抗氧化水平）的影响。
从 2023 年 7 月 1 日开始，对 PubMed、Embase、CNKI 和 Cochrane 图书馆数据库进行了文献检索，没有语言和国家限制。选择了 24 项涉及 512 名接受透析治疗患者的实验研究进行荟萃分析。接受血液透析（HD）的患者血液中的抗氧化标志物水平随着长期 VEM 治疗而提高（p = 0.016）。根据每个抗氧化指标的发现，红细胞衍生的 SOD（p = 0.047）、CAT（p = 0.029）和血浆衍生的总抗氧化水平（p < 0.001）显著增加。口服维生素 E 摄入可显著提高接受 HD 治疗患者的抗氧化标志物水平（p < 0.001）。口服维生素 E 制剂干预 2-6 个月后，红细胞衍生的 SOD（p = 0.003）、GPX（p < 0.001）和 CAT（p = 0.001）显著改善。接受腹膜透析（PD）治疗的患者的抗氧化指标不受口服维生素 E 治疗的影响（p = 0.945）。
维生素 E 治疗对接受透析治疗的患者抗氧化化合物的保留具有有益作用。
