Department of Nursing, Chongqing Public Health Medical Center, Chongqing, China.
PLoS One. 2024 Jul 25;19(7):e0307656. doi: 10.1371/journal.pone.0307656. eCollection 2024.
People living with HIV (PLWH) are susceptible to social isolation as a result of stigma and discrimination, which not only diminishes adherence to antiretroviral therapy but also heightens the risks of hospital readmission, depression, and mortality. However, there is currently no systematic review addressing the occurrence and impact of social isolation in individuals with HIV. Therefore, this study undertook a comprehensive systematic review and meta-analysis of existing literature to examine the prevalence and influencing factors associated with social isolation among PLWH.
PubMed, EMBASE, CINAHL, Cochrane Library, Web of Science, Google Scholar, China Science and Technology Journal Database, The China National Knowledge Infrastructure, WanFang Data and Chinese Biomedicine Literature Database will be searched from the establishment of the database to the latest search date. Literature screening, data extraction and literature quality assessment will be done independently by two researchers and results will be cross-referenced. Data analysis will be performed using stata15.1 software. Risk of publication bias will be assessed using Begg's and Egger's methods. Heterogeneity between studies will then be assessed using the I2 index and its 95% CI and Q statistics. Sources of heterogeneity will be accounted for by subgroup and sensitivity analyses.
The results may reveal the prevalence of social isolation among PLWH and provide data support for understanding its etiology and prevention.
By systematically reviewing the existing literature on social isolation among PLWH, this study aims to provide a comprehensive understanding of the prevalence of social isolation within this population, elucidate the detrimental effects it poses for people affected by HIV, and effectively inform targeted interventions for high-risk groups. Furthermore, these findings offer valuable insights to support evidence-based decision-making in public health policy.
PROSPERO registration number: CRD42024499044.
由于污名化和歧视，感染艾滋病毒的人（PLWH）容易遭受社会孤立，这不仅会降低他们对抗逆转录病毒治疗的依从性，还会增加他们再次住院、抑郁和死亡的风险。然而，目前尚无系统评价研究关注 HIV 感染者的社会隔离发生情况及其影响。因此，本研究对现有文献进行了全面的系统评价和荟萃分析，以研究 PLWH 社会隔离的发生率和相关影响因素。
将从建库起至最新检索日期，通过 PubMed、EMBASE、CINAHL、Cochrane 图书馆、Web of Science、Google Scholar、中国科技期刊数据库、中国国家知识基础设施、万方数据和中国生物医学文献数据库进行文献检索。文献筛选、数据提取和文献质量评估将由两位研究人员独立进行，并进行交叉核对。使用 stata15.1 软件进行数据分析。使用 Begg 法和 Egger 法评估发表偏倚风险。然后使用 I2 指数及其 95%CI 和 Q 统计量评估研究之间的异质性。通过亚组和敏感性分析来解释异质性的来源。
结果可能揭示 PLWH 社会隔离的发生率，并为了解其病因和预防提供数据支持。
通过系统评价 PLWH 社会隔离的现有文献，本研究旨在全面了解该人群中社会隔离的发生率，阐明其对 HIV 感染者的不利影响，并为高风险群体提供有效的针对性干预措施提供数据支持。此外，这些发现为支持公共卫生政策的循证决策提供了有价值的见解。
PROSPERO 注册号：CRD42024499044。
