Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Department of Clinical Neurophysiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
J Appl Physiol (1985). 2024 Sep 1;137(3):757-764. doi: 10.1152/japplphysiol.00748.2023. Epub 2024 Jul 25.
Muscle sympathetic nerve responses to sudden sensory stimuli have been elucidated in several studies on young healthy men, showing reproducible interindividual differences ranging from varying degrees of inhibition to no significant change, with very few subjects showing significant excitation. These individual response patterns have been shown to predict the neural response to mental stress and coupled blood pressure responses. The aim of this study was to investigate whether premenopausal healthy women show similar neural and blood pressure responses. Muscle sympathetic nerve recordings from the peroneal nerve were performed in 34 healthy women (mean age 27 ± 8 yr) during sudden sensory stimuli (electrical stimuli to a finger) and 3 min of mental stress (forced arithmetics). After sensory stimuli, 18 women showed varying degrees of inhibition of muscle sympathetic nerve activity (burst amplitude mean reduction 60%, range 34-100%). The remaining 16 showed no inhibition (mean 5%, range -31 to 28%; one subject exhibiting excitation). During 3 min of mental stress, the normalized change in burst incidence for muscle sympathetic nerve activity correlated with the percentage change of muscle sympathetic nerve activity induced by the sensory stimulation protocol (r = 0.64, = 0.0042). In contrast to men, the neural responses did not predict changes in blood pressure. Thus, premenopausal females show a similar range of individual differences in defense-related muscle sympathetic neural responses as men, but no associated differences in blood pressure responses. Whether these patterns are unchanged after menopause remains to be investigated. Muscle sympathetic neural responses to sudden sensory stimuli in premenopausal women showed interindividual differences and the distribution of sympathetic responses was similar to that previously found in men. Despite this similarity, the associated differences in transient blood pressure responses seen in men were not found in women. The increased risk of developing hypertension in postmenopausal women warrants an investigation of whether these response patterns are altered after menopause.
已有多项研究阐述了年轻健康男性对突发感觉刺激的肌肉交感神经反应，结果显示，个体间存在从不同程度抑制到无显著变化的可再现差异，仅有极少数受试者表现出显著兴奋。这些个体反应模式已被证明可以预测神经对精神应激和耦合血压反应的反应。本研究旨在探讨绝经前健康女性是否表现出类似的神经和血压反应。对 34 名健康女性（平均年龄 27±8 岁）的腓肠神经进行肌肉交感神经记录，在突发感觉刺激（手指电刺激）和 3 分钟精神应激（强制算术）期间进行。在感觉刺激后，18 名女性表现出肌肉交感神经活动的不同程度抑制（爆发幅度平均降低 60%，范围 34%-100%）。其余 16 名女性没有抑制（平均 5%，范围-31%至 28%；一名受试者表现出兴奋）。在 3 分钟的精神应激期间，肌肉交感神经活动爆发发生率的归一化变化与感觉刺激方案引起的肌肉交感神经活动的百分比变化相关（r=0.64，P=0.0042）。与男性不同，神经反应不能预测血压变化。因此，绝经前女性在防御相关的肌肉交感神经反应中表现出与男性相似的个体差异范围，但血压反应没有差异。绝经后这些模式是否保持不变仍有待研究。绝经前女性对突发感觉刺激的肌肉交感神经反应存在个体间差异，且交感反应的分布与之前在男性中发现的相似。尽管存在这种相似性，但在女性中并未发现男性中存在的与短暂血压反应相关的差异。绝经后女性患高血压的风险增加，这需要研究这些反应模式在绝经后是否发生改变。
