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探索病毒组:人类健康与疾病的重要组成部分。

Exploring the virome: An integral part of human health and disease.

机构信息

Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Pathol Res Pract. 2024 Aug;260:155466. doi: 10.1016/j.prp.2024.155466. Epub 2024 Jul 14.

Abstract

The human microbiome is a complex network of microorganisms that includes viruses, bacteria, and fungi. The gut virome is an essential component of the immune system, which is responsible for regulating the growth and responses of the host's immune system. The virome maintains a crucial role in the development of numerous diseases, including inflammatory bowel disease (IBD), Crohn's disease, and neurodegenerative disorders. The human virome has emerged as a promising biomarker and therapeutic target. This comprehensive review summarizes the present understanding of the virome and its implications in matters of health and disease, with a focus on the Human Microbiome Project.

摘要

人类微生物组是一个由微生物组成的复杂网络,包括病毒、细菌和真菌。肠道病毒组是免疫系统的重要组成部分,负责调节宿主免疫系统的生长和反应。病毒组在许多疾病的发展中起着至关重要的作用,包括炎症性肠病(IBD)、克罗恩病和神经退行性疾病。人类病毒组已成为有前途的生物标志物和治疗靶点。这篇综合综述总结了目前对病毒组及其在健康和疾病问题中的意义的理解,重点介绍了人类微生物组计划。

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