van Vliet M A, Martin C B, Nijhuis J G, Prechtl H F
Early Hum Dev. 1985 Nov;12(2):183-97. doi: 10.1016/0378-3782(85)90181-1.
Behavioural state observations were carried out on 12 fetuses which subsequently had birthweights below the 10th percentile. Their gestational ages at the time of study ranged from 32 to 40 weeks. Real-time ultrasound scanning was used to detect fetal body and eye movements, and the fetal heart rate was continuously recorded using a clinical fetal monitor. None of these fetuses was severely acidemic or depressed at birth. Findings in the growth-retarded fetuses were compared with those obtained in the fetuses of 14 low risk nulliparae and 14 low risk multiparae by means of the same techniques (van Vliet et al. (1985) Early Hum. Dev., 12, 121-135.; Nijhuis et al. (1982) Early Hum. Dev., 6, 177-195). The appearance of states seemed to be delayed in the growth-retarded fetuses. States were present in only three of eight growth-retarded fetuses studied at 40 weeks, whereas only one of 16 low risk fetuses did not show states at this age. Also at 40 weeks, the proportion of discordant association of the state variables was increased in the growth-retarded fetuses in comparison to the low risk group. There were no consistent differences between the two groups in the occurrence of defined combinations of parameters of the state variables at earlier ages. The growth-retarded fetuses showed differences in the quality and quantity of somatic motility in comparison to low risk fetuses of equivalent gestational age. These observations suggest that some aspects of central nervous system function are disturbed in growth-retarded fetuses, even in the absence of fetal distress.
对12名出生体重低于第10百分位数的胎儿进行了行为状态观察。研究时他们的胎龄在32至40周之间。使用实时超声扫描检测胎儿身体和眼睛运动，并使用临床胎儿监护仪持续记录胎儿心率。这些胎儿出生时均无严重酸中毒或抑制情况。通过相同技术，将生长受限胎儿的观察结果与14名低风险初产妇和14名低风险经产妇的胎儿的观察结果进行比较（van Vliet等人（1985年）《早期人类发育》，12卷，第121 - 135页；Nijhuis等人（1982年）《早期人类发育》，6卷，第177 - 195页）。生长受限胎儿的状态出现似乎延迟。在40周时研究的8名生长受限胎儿中只有3名出现了状态，而在这个年龄16名低风险胎儿中只有1名未表现出状态。同样在40周时，与低风险组相比，生长受限胎儿状态变量不一致关联的比例增加。在较早年龄时，两组在状态变量参数的特定组合出现情况方面没有一致的差异。与同等胎龄的低风险胎儿相比，生长受限胎儿在躯体运动的质量和数量上存在差异。这些观察结果表明，即使在没有胎儿窘迫的情况下，生长受限胎儿的中枢神经系统功能的某些方面也受到了干扰。
